46 Detection of HBV Genotype C in Hepatocellular Carcinoma Patients From North-East India

Sarma, MP; Medhi, Subhash; Goswami, Bhabadev; Thayumanavan, L; Ahmed, G; P, Kar

doi:10.1016/s0973-6883(12)60047-4

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As multiple studies clarified the influence of HBV genotypes on the natural history and the outcome of HBV infection, it is likely that certain genotypes may increase the risk of HCC development. A study from north-eastern India showed predominance of genotype D followed by similar prevalence of genotypes A and C in HCC patients [33]. Another Indian study also reported the role of genotype D (odds ratio, OR = 1.8) and mixed genotypes (odds ratio, OR = 6.9) and higher viral load in HCC risk [34].…”

Section: Influence Of Hbv Genotypes On Hcc Developmentmentioning

confidence: 96%

Hepatitis B genotyping: The utility for the clinicians

Fletcher

Eapen

Abraham

2019

Indian J Gastroenterol

View full text Add to dashboard Cite

Section: Influence Of Hbv Genotypes On Hcc Developmentmentioning

confidence: 96%

Hepatitis B genotyping: The utility for the clinicians

Fletcher

Eapen

Abraham

2019

Indian J Gastroenterol

View full text Add to dashboard Cite

“…The most common etiological factor for HCC is the cirrhotic liver, which provides a pro-carcinogenic intrahepatic environment (4,5). The most notable risk factors, including chronic viral hepatitis caused by hepatitis B virus (HBV) or hepatitis C virus infection, alcohol abuse, non-alcoholic fatty liver disease and other abnormal metabolic conditions, contribute to the development of cirrhosis, particularly in East Asian countries where HBV infection is endemic (6)(7)(8). HCC is generally diagnosed in individuals at an advanced stage due to the lack of early symptoms (6).…”

Section: Introductionmentioning

confidence: 99%

RPLP1 is highly expressed in hepatocellular carcinoma tissues and promotes proliferation, invasion and migration of human hepatocellular carcinoma Hep3b cells

et al. 2021

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is a common primary malignant tumor with a high mortality rate. Increasing evidence suggests that ribosomal protein LP1 (RPLP1) is involved in the progression of different types of cancer. Thus, the present study aimed to investigate the underlying molecular mechanism of RPLP1 in HCC progression. The cellular behaviors of Hep3b cells were assessed via Cell Counting Kit-8, colony formation, wound healing and Transwell assays. Western blot analysis was performed to detect protein expression levels, while reverse transcription-quantitative PCR analysis was performed to detect mRNA expression levels. The results demonstrated that RPLP1 was highly expressed in HCC tissues and cells, and the overexpression of RPLP1 was associated with a less favorable prognosis of patients with HCC. Notably, downregulation of RPLP1 significantly suppressed the proliferation, migration and invasion of Hep3b cells. Taken together, the results of the present study suggested that RPLP1 acts as an oncogene in HCC, and thus may be used to treat patients with HCC.

show abstract

46 Detection of HBV Genotype C in Hepatocellular Carcinoma Patients From North-East India

Cited by 2 publications

References 0 publications

Hepatitis B genotyping: The utility for the clinicians

Hepatitis B genotyping: The utility for the clinicians

RPLP1 is highly expressed in hepatocellular carcinoma tissues and promotes proliferation, invasion and migration of human hepatocellular carcinoma Hep3b cells

Contact Info

Product

Resources

About