449 Jejunoileal Gradient of Sucrase Activity Is Programmed in Fetal Rats in Utero

Abstract

L(XJ SERUM 3,3 ' ,5 ' TRIIODOTHYRONINE (REVERSE T3) CON-CENTRATION IN BURNED CHILDREN AND ITS RELATIONSHIP TO NUTRITIONAL STATE. Craig L. Kien, William J . Vanjonack, and Hans 11. Bode. Harvard Medical School, S h r i n e r s Burns I n s t i t u t e , Dept. of P e d i a t r i c s , Boston and MIT, Dept. of N u t r it i o n , Cambridge, Mass. We s t u d i e d the c o r r e l a t i o n between p r o t e i n turnover and serum thyroid hormone l e v e l s i n 10 c h i l d r e n , age 1-16 y r s . , w i t h s e v e r burn i n j u r i e s . Whole body r o t e i n s y n t h e s i s (S) and breakdown(C) were determined using an (P5N) g l y c i n e i n f u s i o n technique. P a t i e n t s were maintained i n good n u t r i t i o n a l s t a t u s a s evidenced by a n e t anabolism (SfC) i n 14 of 21 s t u d i e s . There was no change i n mean l e v e l s of serum 3 , 3 ' ,5' t r i i o d o t h y r o n i n e (T3), a decrease i n serum thyroxine (T4) and a s u p p r e s s i o n of serum r ev e r s e T? l e v e l s .Burned (I?I + S.D.) C o n t r o l s p Value Age ( y r . ) 9 . 2 + 4 . 5 (n=10) 11.8 + 3.9 ( n = l l ) p 7 . 0 5 T4 (ug%) 6.4 + 1 . 6 (n=lO)T3 (ng%) 152 5 7 1 (n=10) 146 2 23 (n=14) p 7 . 0 5 rT3 ( n g % ) 1 5 . 9 + 1 7 . 7 ( n = l O ) 5 0 . 8 + 1 4 . l ( n = 1 4 ) p~. 0 0 0 5 rT3IT4 2.2 + 2.1 (n=10) 5 . 8 + 1.6 ( n = l l ) p~. 0 0 5The d i f f e r e n c e between p r o t e i n s y~t h e s i s and breakdown (S i n u s C) was n e g a t i v e l y c o r r e l a t e d w i t h t h e K T~/ T~ r a t i o a d e c r e a s e i n N balance was a s s o c i a t e d i t h a r i s e i n rT3!T3 r a t i o , s i m i l a r t o o b s e r v a t i o n s made i n umans during f a s t~n g o r s e v e r e s t r e s s . These s t u d i e s suggest be u s e f u l c l i n i c a l l y a s an i n d i c a t o r f r e l a t i v e d i e t a r y energy d e f i c i e n c y . 448 USE OF ORAL NUTRITIONAL SUPPLEMENTS TO REVERSE GROWT RETARDATION IN CHILDREN WITH CROHN'S DISEASE.Sucrase a c t i v i t y i s a b s e n t i n t h e small i n t e s t i n e of f e t a l r a t s , but i t i n c r e a s e s d u r i n g t h e weaning p e r i o d . At t h e same time, i t s j e j u n o i l e a l g r a d i e n t , known t o e x i s t i n most a d u l t mammals, appears. Mechanisms l e a d i n g t o t h e expression of biochemical s p e c i a l i z a t i o n of i n d i v i d u a l s e c t i o n s of t h e s m a l l i n t e s t i n e a r e n o t c l e a r .Fragments of f e t a l r a t jejunum and ileum (21-day o l d , CDF s t r a i n C h a r l e s River Farm) implanted under t h e kidney c a p s u l a of a d u l t r a t s (Gastroent. 64:292 and J . End. 74:145) were assayed a f t e r 4 and 6 weeks f o r s u c r a s e a c t i v i t y and compared w i t h small COMBINED GI ALLERGY AND IMMUNOGLOBULIN DEFICIENCY: ROLE OF CROMOLYN. Samuel Kocoshis and Joyce Gryboski i n t e s t i n e developing i n s i t u . Ninety-eight i n f a n t s f u l f i l l e d c r i t e r i a f o r G I a l l e r g y a f t e r d i s a c c h a r i d e t o l e r a n c e t e s t s and s m a l l ...