449 A randomized controlled trial comparing teo protocols fir the use of misoprostol in mid-trimester pregnancy termination

Bebbington, Michael; Kent, Nancy; Lim, Kenneth; Gagnon, Alain; Delisle, Marie France; Tessier, Francine; Money, Deborah; Williams, Keith Philip; Galerneau, France; Wilson, D. G.

doi:10.1016/s0002-9378(01)80481-6

Cited by 7 publications

(8 citation statements)

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“…Out of these, 32 (32.3%) patients had anhydramnios (study group) and 67 (67.7%) had some anomalies with normal amniotic fluid (control group). Mean patient age was 28.10 ± 5.72 (15-41) and mean gestational age was 17.94 ± 3.40 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) weeks. Sixty-one (61.6%) patients had previous vaginal delivery, 28 (28.3%) had previous cesarean section, and 10 (10.1%) patients were nulliparous.…”

Section: Resultsmentioning

confidence: 99%

“…Prostaglandins are the mainstay of medical terminations over 13 weeks of gestation, either as a single drug or combined with mifepristone [10,11]. Misoprostol has been applied in different doses and routes for the second trimester TOP [12]. Various doses have been used, ranging from 200 to 800 μg at intervals ranging from 3 to 12 h [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

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Does the presence of anhydramnios affect the duration of medical abortion?

Karapınar

Güngören²,

Dolapçıoğlu³

et al. 2016

Ginekol Pol

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Objectives: The aim of the study was to determine whether anhydramnios affected the duration of medical abortion in cases with various indications as compared to cases with normal amniotic fluid volume. Material and methods:Patients who were admitted to our clinic because of medical abortion between January 2010-December 2013 were included in this retrospective study. A total of 32 pregnant women with anhydramnios (study group) and 67 pregnant women with normal amniotic fluid volume but with fetal abnormality (control group) were included in the study. Patient age, gravidity, parity, gestational age, previous delivery route, and duration of the abortion were recorded.Results: Mean duration of the abortion in the study group was 71.93 ± 47.51 h as compared to 79.08 ± 52.62 h in the control group. There were no statistically significant differences between the two groups in terms of duration of the abortion (p = 0.516). Also, we found no statistically significant differences in duration of the abortion with regard to previous delivery route (p = 0.220).Conclusions: There were no statistically significant differences between the study group and controls in terms of duration of the abortion. In addition, neither parity nor previous delivery route affected the duration of the abortion.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Does the presence of anhydramnios affect the duration of medical abortion?

Karapınar

Güngören²,

Dolapçıoğlu³

et al. 2016

Ginekol Pol

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show abstract

“…4 According to their results, significantly more patients were delivered in vaginal group within 24 hours (85.50 versus 9.50%). Behrashi M et al observed in their study that the delivery percentage of vaginal group was significantly higher than oral group (86.7 versus 43.30, p value is 0.0006).…”

Section: Discussionmentioning

confidence: 97%

Randomized comparative study of safety and efficacy of oral and vaginal misoprostol in the termination of second trimester pregnancy at tertiary care institution

Lujimmala

Anitha

2017

Int J Reprod Contracept Obstet Gynecol

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Background: A prospective randomized study was conducted in 72 pregnant women, with gestational period between 12 and 20 weeks, to compare the efficacy and safety of oral versus vaginal administration of misoprostol for second trimester pregnancy termination. The study was conducted in the Department of Obstetrics and Gynaecology, Government Kilpauk Medical College and Hospital (KMCH), Chennai, South India from November 2012 and November 2013.Methods: Women aged 18-38 years requesting MTP for maternal reason, foetal congenital anomalies and intrauterine foetal demise were randomly assigned into two groups. Group A (n=36) had misoprostol orally while the Group B (n=36) received misoprostol by vaginal route. Dosage regimen was similar in both the groups that was 200µg every 4 hrs until the abortion occurred, maximum up to 6 doses. Efficacy included induction to delivery interval and safety included maternal complications and side-effects like nausea, vomiting, diarrhoea, fever and abdominal pain and results were compared.Results: The percentage of women who delivered was significantly higher in the vaginal group than the oral group (94.44% versus 66.67%, P <0.03018) within 24 hours. The induction to delivery interval and incidence of side-effects were noted.Conclusions: Vaginal administration of misoprostol resulted in a higher success rate and misoprostol is safe and effective drug for second trimester pregnancy termination.

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“…3,4 The vaginal route is also more effective than the oral route. [5][6][7][8] The greater bioavailability of vaginal Misoprostol probably explains the clinical results.…”

Section: Introductionmentioning

confidence: 99%