“…Whereas in the United States impinger measurements with counting of single particles (''mppcf''), where the base of the recalculation process, in Australia konimeter data and later gravimetric sampling (''total dust'' and respirable dust) were used. In the Chinese cohorts, a local instrument for the gravimetric determination of total dust was applied (Zhuang et al 2001;Dahmann et al 2004), however, the highest exposure concentration used in the respective job-exposure matrices was set to 25 mg/m 3 of total dust (Zhuang et al 2001). This seems to clearly indicate an underestimation of exposures, at least during the times when dry drilling, was applied.…”
It is absolutely necessary to invest sufficient effort for the estimation of exposure situations of past technological environments. Especially, the situation of early mechanised mining, characterised by low ventilation, dry drilling techniques and generally lacking dust control measures was characterized by extreme shift exposures. It is important to keep these in mind when metal mining exposure in different environments is considered.
“…Whereas in the United States impinger measurements with counting of single particles (''mppcf''), where the base of the recalculation process, in Australia konimeter data and later gravimetric sampling (''total dust'' and respirable dust) were used. In the Chinese cohorts, a local instrument for the gravimetric determination of total dust was applied (Zhuang et al 2001;Dahmann et al 2004), however, the highest exposure concentration used in the respective job-exposure matrices was set to 25 mg/m 3 of total dust (Zhuang et al 2001). This seems to clearly indicate an underestimation of exposures, at least during the times when dry drilling, was applied.…”
It is absolutely necessary to invest sufficient effort for the estimation of exposure situations of past technological environments. Especially, the situation of early mechanised mining, characterised by low ventilation, dry drilling techniques and generally lacking dust control measures was characterized by extreme shift exposures. It is important to keep these in mind when metal mining exposure in different environments is considered.
“…Furthermore, setting scientifically based limit values is complicated, owing to the difficulties in interpreting heterogeneous experimental and epidemiological findings (Chen et al 2001a;OEHHA 2005;Zhuang et al 2001). Despite much recent progress in our understanding of source attribution, emission factors, and regulation of silica (Chen et al 2012;Rong et al 2013;Sellamuthu et al 2013), current risk assessment models based on parameterization of laboratory experiments cannot fully explain the magnitude of silica-induced pulmonary disease risk.…”
Section: Responsible Editor: Marcus Schulzmentioning
Inhalation of silica (SiO2) in occupational exposures can cause pulmonary fibrosis (silicosis), lung function deficits, pulmonary inflammation, and lung cancer. Current risk assessment models, however, cannot fully explain the magnitude of silica-induced pulmonary disease risk. The purpose of this study was to assess human health risk exposed to airborne silica dust in Taiwan ceramics manufacturing. We conducted measurements to characterize workplace-specific airborne silica dust in tile and commodity ceramic factories and used physiologically based alveolar exposure model to estimate exposure dose. We constructed dose-response models for describing relationships between exposure dose and inflammatory responses, by which health risks among workers can be assessed. We found that silica contents were 0.22-33.04 % with mean concentration ranges of 0.11-5.48 and 0.46-1763.30 μg m(-3), respectively, in commodity and tile ceramic factories. We showed that granulation workers in tile ceramic factory had the highest total SiO2 lung burden (∼1000 mg) with cumulative SiO2 lung burden of ∼4 × 10(4) mg-year. The threshold estimates with an effect on human lung inflammation and fibrosis are 407.31 ± 277.10 (mean ± sd) and 505.91 ± 231.69 mg, respectively. For granulation workers, long-term exposure to airborne silica dust for 30-45 years was likely to pose severe adverse health risks of inflammation and fibrosis. We provide integrated assessment algorithms required to implement the analyses and maintain resulting concentration of silica dust at safety threshold level in the hope that they will stimulate further analyses and interpretation. We suggest that decision-makers take action to implement platforms for effective risk management to prevent the related long-term occupational disease in ceramics manufacturing.
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