“…38 ChIPSeq genome-wide analysis of HBx chromatin recruitment revealed a specific binding of HBx to a large number of new and known HBx target sequences. 39 Systematic integrative analysis of the over 6,000 genes potentially regulated by HBx shows an enrichment in genes involved in cell metabolism, cell signaling, chromatin dynamics, and cancer but HBV replication (Ras, calcium transport, endocytosis, MAPK/WNT pathways, Src, the EGF/HGF family) as well. 37 HBx also binds to 115 miRNAs (70 putative miRNA promoters and 45 mirtrons), including mir224, mir21, and other miRNA deregulated in cancer, miRNA that control other cellular functions (i.e., miR26b, miR-502) and miRNAs that affect HBV replication (miR224, miR138, miR596, and others).…”