431 Efficacy of Autologous Conditioned Serum (Acs-Orthokine) in Osteoarthritis of the Knee at Two Year Follow-Up. The German Orthokine Osteoarthritis Trial – Goat-

Moser, Claudia; Baltzer, A. W. A.; Jansen, S.A.; Krauspe, R.; Wehling, Peter

doi:10.1016/s1063-4584(07)62062-7

Cited by 2 publications

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“…Patients in the three groups underwent six injections of ACS or hyaluronic acid or normal saline (as a placebo) at a 6-month follow up. A significant improvement in the outcome measures was reported in the ACS group compared with the other intervention groups, without any side effects [ 29 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of intra-articular autologous-conditioned Serum Injection in Knee Osteoarthritis: a meta-analysis Study

et al. 2021

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Aim: Knee osteoarthritis is a common disabling disorder, with no curative treatment. This study aims to assess autologous conditioned serum effectiveness in its treatment. Materials & methods: Following a systematic search (2000–2020) on major databases and screening and filtering processes, eight articles were included in the final analyses. The pooled effect of visual analog scale (VAS) and the Western Ontario and McMaster Universities (WOMAC) variables was evaluated before and after the intervention. Results: The combined standardized mean difference for the global WOMAC score was -2.44 and the combined weighted mean difference was -22.92. The combined standardized mean difference for the VAS score was -3.77 and the combined weighted mean difference was -32.37 (p < 0.000). Conclusion: This meta-analysis reported that the autologous conditioned serum can reduce pain and improve function (VAS and WOMAC outcome measures) in patients with knee osteoarthritis.

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Section: Discussionmentioning

confidence: 99%

“…It is noteworthy that these researchers followed 310 of these patients over the next 2 years and re-reported the long-term efficacy and safety of ACS and its superiority to the control group [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of intra-articular autologous-conditioned Serum Injection in Knee Osteoarthritis: a meta-analysis Study

et al. 2021

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“…Pain scores were 39 and 37 for the HA and saline groups, respectively. Notably, the effects seen in the HA and saline groups also persisted for the additional 18 months [59]. Another randomized controlled trial (RCT) compared Orthokine-produced ACS with a saline control [58].…”

Section: Fox and Stephensmentioning

confidence: 97%

Treatment of knee osteoarthritis with Orthokine^®-derived autologous conditioned serum

Fox

Stephens

2010

Expert Review of Clinical Immunology

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Osteoarthritis (OA) is the most prevalent arthritis in the world with increasing numbers of people expected to acquire the disease as the population ages. Therapies commonly used to manage the disease have limited efficacy and some carry significant risks. Current data suggest that the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1Ra) can alter the inflammatory response and cartilage erosion present in OA. Intra-articular gene expression of IL-1Ra has shown promising results in animal models to provide symptomatic improvement and minimize osteoarthritic changes. Orthogen AG (Dusseldorf, Germany) has developed a method to produce an autologous conditioned serum (ACS) rich in IL-1Ra marketed as Orthokine. Study participants treated with ACS have improved pain and function; however, these results are preliminary and need confirmation. If ongoing trials prove that ACS can retard cartilage degeneration and reduce inflammation, the management of OA would be dramatically altered, perhaps providing a mechanism to prevent the disease or at least its progression.

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431 Efficacy of Autologous Conditioned Serum (Acs-Orthokine) in Osteoarthritis of the Knee at Two Year Follow-Up. The German Orthokine Osteoarthritis Trial – Goat-

Cited by 2 publications

References 0 publications

Effectiveness of intra-articular autologous-conditioned Serum Injection in Knee Osteoarthritis: a meta-analysis Study

Effectiveness of intra-articular autologous-conditioned Serum Injection in Knee Osteoarthritis: a meta-analysis Study

Treatment of knee osteoarthritis with Orthokine^®-derived autologous conditioned serum

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431 Efficacy of Autologous Conditioned Serum (Acs-Orthokine) in Osteoarthritis of the Knee at Two Year Follow-Up. The German Orthokine Osteoarthritis Trial – Goat-

Cited by 2 publications

References 0 publications

Effectiveness of intra-articular autologous-conditioned Serum Injection in Knee Osteoarthritis: a meta-analysis Study

Effectiveness of intra-articular autologous-conditioned Serum Injection in Knee Osteoarthritis: a meta-analysis Study

Treatment of knee osteoarthritis with Orthokine®-derived autologous conditioned serum

Contact Info

Product

Resources

About

Treatment of knee osteoarthritis with Orthokine^®-derived autologous conditioned serum