428. Neurophysiological Mechanisms of Cortical Learning Plasticity Impairments in Schizophrenia and Modulation by the N-Methyl-D-Aspartate Type Glutamate Receptor Agonist D-Serine

Kantrowitz, Joshua T.; Epstein, M. A.; Beggel, Odeta; Rohrig, Stephanie; Lehrfeld, Jonathan M.; Revheim, Nadine; Lehrfeld, Nayla; Reep, Jacob; Parker, Emily M.; Silipo, Gail; Ahissar, Merav; Javitt, Daniel C.

doi:10.1016/j.biopsych.2017.02.912

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“…Severely impaired TMT performance in schizophrenia is independent from psychotic symptoms, present in about half of those diagnosed, correlates significantly with early cortical measures of auditory processing such as MMN deficits, and contributes directly to impairments in higher cognitive functions such as attention and memory (Donde et al, submitted;Donde et al, 2017;Javitt, 2009;Javitt and Sweet, 2015;Lee et al, 2018;Petkova et al, 2014). Further, behavioral improvements on the TMT during auditory training correlate with changes in MMN (Javitt et al, 2000;Kantrowitz et al, 2016). Taken together, these qualities of the TMT make it a good candidate for use as a tailoring variable when assigning clinic-based treatments that involve EAP training.…”

Section: Introductionmentioning

confidence: 99%

Impact of baseline early auditory processing on response to cognitive remediation for schizophrenia

Medalia

Saperstein

Qian

et al. 2019

Schizophrenia Research

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Background: Early auditory processing (EAP) has increasingly become a focus of efforts to identify biomarkers of treatment response in schizophrenia. EAP deficits lead to poor functional outcome via impaired cognition, and treatments that target EAP may drive downstream cognitive improvements. Assessment of baseline need provides an opportunity for cognitive remediation (CR) programs that give EAP training to personalize treatment and optimize its impact. This initial efficacy study examined the differential benefit of EAP training for those with and without baseline EAP deficits as defined by performance on the Tone Matching Test.Methods: 103 outpatient adults diagnosed with schizophrenia or schizoaffective disorder were classified as having intact (48.5%) or impaired (51.5%) EAP and randomized to a CR program with restorative exercise plans that either included EAP training (N = 49) or did not (N = 54). Cognitive and functional outcomes were measured post-treatment and 3 months later.Results: Only in EAP impaired participants was there a significant benefit from EAP training on verbal learning. Treatment condition did not significantly impact global cognitive or functional outcomes for either EAP group. Cognitive gains partially mediated the relationship between gains in EAP and functional capacity.

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