Abstract:The 5α-reductase enzyme converts testosterone to dihydrotestosterone, the most potent androgen in certain tissues such as the hair follicle. Increased activity of this enzyme has been seen in the ovaries of patients with polycystic ovary syndrome (PCOS), the most common endocrinopathy in reproductive-aged women. Increased activity of this enzyme may have important clinical implications in PCOS. For example, 5α-reduced androstenedione inhibits aromatase in the ovaries, reducing estrogen production, a possible c… Show more
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