Introduction: Androgen deprivation therapy (ADT) for advanced prostate cancer can be associated with side effects which may negatively impact quality of life (QoL) and induce serious medical problems. Aim: The aim is to give practical recommendations on how to monitor and counsel patients and effectively manage side effects based on relevant original articles, review articles and abstracts. Results: Urologists should be aware of side effects and adapt their practice patterns to rapidly recognize these and administer appropriate treatment. Proper counseling of ADT-treated patients is needed to help them recognize and prevent and/or manage side effects. Patients should be encouraged to adopt a healthy lifestyle such as a healthy diet and physical exercise. In addition, bone mineral density and metabolic and cardiovascular parameters need to be carefully monitored. Conclusions: Urologists should take appropriate measures to prevent and manage ADT-related side effects to promote the general health and overall QoL of patients.