417–2α‐Tocopherol and ascorbic acid attenuates the ribavirin‐induced decrease of eicosapentaenoic acid in erythrocyte membrane in chronic hepatitis C patients

Abstract

Supplementation of alpha-tocopherol and ascorbic acid attenuates the ribavirin-induced decrease of EPA in erythrocyte membrane phospholipids in chronic hepatitis C patients.

Can eicosapentaenoic acid maintain the original ribavirin dose or affect the response during the treatment course of chronic hepatitis C virus (HCV) patients?

“…Our results also agree with Hino et al (14) who concluded that fish-derived omega-3s supplementation enabled stopping the premature destruction of RBCs by maintaining the ecosapentaenoic acid level in their cell membranes from decreasing because of interferon therapy. Hino et al (14) also ascertained that the oxidative damage in erythrocyte membrane plays an important role in RBV-induced anemia.…”

Meta‐analysis: antioxidant supplements for liver diseases – the Cochrane Hepato‐Biliary Group

“…20 randomized trials [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] (Table 2).…”

“…37,38,50 Three trials treated all participants with interferon 37,38,40 and two trials treated all participants with interferon and ribavirin. 45,48 Control interventions Thirteen trials used placebo as control intervention. Seven trials had no intervention in the control group.…”

“…40,47 Seven of the trials provided data on all-cause mortality, 33, 37, 42-44, 49, 50 three trials on liver-related mortality, 33,43,44 three trials on liver-related morbidity 34,36,50 and five trials on adverse events. 31,37,39,42,48 Ten (50%) of the trials mentioned that antioxidant supplements were provided by pharmaceutical companies. This information was not available in the remaining ten trials.…”

“…Several adverse events were reported in the experimental group of the included trials (liver function test elevation; 31 dyspepsia and fatigue, leucocytopaenia, thrombocytopaenia, autoimmune thyroiditis, depression; 37 general fatigue, anorexia, and ⁄ or depression; 48 arthralgia, diarrhoea, dyspepsia, dysgeusia, low mood, menorrhagia, shingles, coryza, dizziness, dysuria 42 ). However, the antioxidant supplements were without significant effects on these as well as other adverse events.…”