#416 A randomized phase II trial of high dose alkylating agents plus VP-16 in children with high grade astrocytoma

Arenson, Edward B.; Ater, Joann L.; Bank, J.; Bevan, Herbert E.; Bruner, Janet M.; Cullen, Patricia; Deutsch, Melvin; Holmes, Emi; Luerssen, Thomas G.; O’Brien, Richard T.; Shah, Nilay; Sposto, Richard; Steinbok, Paul; Strain, JJ; Thomson, Jane; Yates, Allen J.

doi:10.1097/00043426-199907000-00085

Cited by 6 publications

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The Treatment of High Grade Gliomas and Diffuse Intrinsic Pontine Tumors of Childhood and Adolescence: A Historical – and Futuristic – Perspective

Finlay

Zacharoulis

2005

J Neurooncol

View full text Add to dashboard Cite

Pediatric high grade gliomas represent a heterogeneous group of tumors with poor prognoses despite the use of multimodal treatment. Very little progress has been made over the past decades in identifying efficacious therapeutic modalities against both high grade gliomas and diffuse brainstem gliomas in children. The degree of surgical resection is the most important clinical prognostic factor for children with high grade gliomas, and a complete resection should be attempted whenever feasible. The role of radiation therapy in the treatment of older children with high grade gliomas and diffuse brain stem gliomas is undisputed; however the benefit of using radiation for patients less than 6 years of age (with high grade gliomas) might be questionable. Despite the absence of solid evidence to support its use, chemotherapy is routinely used against these tumors. Currently temozolomide is being investigated due to its activity in adult trials and based on preliminary data regarding recurrent disease. A small subgroup of patients can be successfully treated with high dose chemotherapy followed by autologous stem cell rescue. Early trials using this modality in the past had been associated with high morbidity and mortality. High dose chemotherapy with autologous stem cell rescue in selected patients with minimal residual disease, angiogenesis inhibitors, radiosensitizers and other biological modifiers are being currently investigated in phase I/II trials.

show abstract

The Treatment of High Grade Gliomas and Diffuse Intrinsic Pontine Tumors of Childhood and Adolescence: A Historical – and Futuristic – Perspective

Finlay

Zacharoulis

2005

J Neurooncol

View full text Add to dashboard Cite

show abstract

New Delivery Approaches for Pediatric Brain Tumors

Pollack

Keating

2005

J Neurooncol

View full text Add to dashboard Cite

For many types of childhood brain tumors, including malignant gliomas, disease progression at the primary site is the predominant mode of treatment failure. Accordingly, interest has been directed during the last decade on exploring strategies to enhance the delivery of therapeutically active agents into the tumor microenvironment. Two approaches that have been the focus of considerable attention in the treatment of adult malignant brain tumors include interstitial administration of chemotherapeutic agents using time-release polymers and convection-enhanced delivery of immunotoxin conjugates targeted to receptors overexpressed in brain tumors relative to normal brain cells. Although it remains to be determined whether these approaches will lead to meaningful improvements in disease control and long-term prognosis in children with brain tumors, the encouraging results from studies in adults support the rationale for further exploring these strategies in the pediatric setting.

show abstract

Supratentorial High-Grade Gliomas

Pollack¹

2005

Textbook of Neuro-Oncology

View full text Add to dashboard Cite

#416 A randomized phase II trial of high dose alkylating agents plus VP-16 in children with high grade astrocytoma

Cited by 6 publications

References 0 publications

The Treatment of High Grade Gliomas and Diffuse Intrinsic Pontine Tumors of Childhood and Adolescence: A Historical – and Futuristic – Perspective

The Treatment of High Grade Gliomas and Diffuse Intrinsic Pontine Tumors of Childhood and Adolescence: A Historical – and Futuristic – Perspective

New Delivery Approaches for Pediatric Brain Tumors

Supratentorial High-Grade Gliomas

Contact Info

Product

Resources

About