Abstract:Background:The first clinical genetically-engineered pig heart transplant has stimulated consideration of which patients might be medically and ethically appropriate to enroll in the initial clinical trials. Beyond exceptional 'compassionate use' applications, as in the University of Maryland case, which patients might be selected for formal 'qualifying' trials of 'destination' or 'bridging' heart xenotransplantation? Approach and Results: Patients eligible for a heart allograft and in whom mechanical circulat… Show more
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