40-year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in England and Wales, 1971–2011: a population-based study

Quaresma, Manuela; Coleman, Michel P; Rachet, Bernard

doi:10.1016/s0140-6736(14)61396-9

Cited by 385 publications

(307 citation statements)

References 21 publications

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“…Both testicular cancer and low Breslow-thickness malignant melanoma have a very good prognosis and high 10-year survival rates [15] (of the 33 melanomas in this study, only 2 had a poorer prognosis, with > 4 mm Breslow thicknesses). Therefore, it is not surprising that patients with such diagnoses were more likely to have employment restrictions lifted quickly.…”

Section: Discussionmentioning

confidence: 53%

Factors in Removing Job Restrictions for Cancer Survivors in the United Kingdom Royal Air Force

Murray¹,

Lam

McLoughlin

et al. 2018

J Occup Rehabil

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Purpose To identify personal, occupational and clinical factors associated with the lifting of restrictions on duties among Royal Air Force (RAF) personnel who have returned to work after surviving primary cancer treatment. Methods A retrospective cohort of 205 RAF personnel aged 18-58 with cancer diagnosed between 2001 and 2011 was followed-up until May 2012. Personal, occupational, and clinical information was extracted from occupational health and primary care records. Predictors of the lifting of (a) employment restrictions on UK duties at 18 months after diagnosis and (b) the lifting of all deployment restrictions at the end of the study were analysed using logistic and Cox regression models. Results At 18 months, 62% of the cancer survivors had restrictions on their UK duties lifted. The positive independent predictors of unrestricted UK duties are testicular cancer (OR 5.34; 95% CI 1.21-23.6) and no treatment being required (16.8; 1.11-255.2). The lifting of all employment restrictions and return to full deployability was achieved by 41% of the participants (median time 2.1 years), with testicular cancer (HR 2.69; 95% CI 1.38-5.26) and age at diagnosis (1.05; 1.01-1.09) being the positive independent predictors of faster lifting of all restrictions. Conclusion Diagnostic group, prognosis and type of treatment are not the only predictor of employment outcome after cancer. Patient-centred factors such as smoking, age, fatigue, job status, job type and length of employment are also important predictors of return to pre-morbid job function in cancer survivors in the RAF.

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Section: Discussionmentioning

confidence: 53%

Factors in Removing Job Restrictions for Cancer Survivors in the United Kingdom Royal Air Force

Murray¹,

Lam

McLoughlin

et al. 2018

J Occup Rehabil

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“…This rationale is enshrined in numerous governmental publications internationally 13,14 Among developed countries, the UK and Denmark have regularly appeared at the bottom of tables ranking the survival of patients with cancer. [15][16][17][18] These poor outcomes, relative to those of similar patients in other developed countries, are considered to arise in a large part from differences in the availability of, and willingness to use cancer diagnostic investigations, perhaps augmented by a decreased willingness of patients in England to seek medical care compared with those in Europe. 19 Investigators in one study reported an inverse relationship between cancer survival rates and the degree of separation of primary care from specialist care in health-care systems (the soprimary care, whereby access to specialist care requires a referral from primary care).…”

Section: [H1] Benefits Of Expedited Symptomatic Diagnosis [H2] Typesmentioning

confidence: 99%

Improving early diagnosis of symptomatic cancer

Hamilton

Walter

Rubin³

et al. 2016

Nat Rev Clin Oncol

108

125

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| Much time, effort and investment goes into the diagnosis of symptomatic cancer, with the expectation that this approach brings clinical benefits. This investment of resources has been particularly noticeable in the UK, which has, for several years, appeared near the bottom of international league tables for cancer survival in economically developed countries. This Review examines expedited diagnosis of cancer from four perspectives. The first examines the potential for benefits from expedited diagnosis of symptomatic cancer. Limited evidence from clinical trials is available, but the considerable observational evidence suggests benefits can be obtained from this approach. The second perspective considers how expedited diagnosis can be achieved. We concentrate on data from the UK, where extensive awareness campaigns have been conducted, and initiatives in primary care, including clinical decision support, have all occurred during a period of considerable national policy change. The third section considers the most appropriate patients for cancer investigations, and the possible community settings for this. UK national guidance for selection of patients for investigation is discussed. Finally, the health economics of the subject are reviewed, although few studies provide definitive evidence on this topic.In all developed countries, much time, effort and finance is spent on the diagnosis of cancer.

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“…7,24 Extended survival of patients with metastases compels the treatment of bone metastases and specifically spine metastases. 15,25 Patchell et al 23 changed the treatment algorithm for epidural tumors demonstrating evident benefit from surgery combined with radiotherapy.…”

Section: Neurosurg Focus 42 (1):e3 2017mentioning

confidence: 99%

Spine radiosurgery: lessons learned from the first 100 treatment sessions

Harel

Pfeffer

Levin

et al. 2017

FOC

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OBJECTIVE Local therapy to spine tumors has been shown to be effective in selected cases. Spinal radiosurgery (SRS) is an evolving radiotherapy regimen allowing for noninvasive, highly efficacious local treatment. The learning curve can compromise the results of any newly employed technology and should be studied to minimize its effects. In this paper the first 100 SRSs performed at several medical centers are presented and analyzed for the effects of the learning curve on outcome. METHODS A retrospective analysis was undertaken to evaluate data from patients treated with SRS at Sheba Medical Center and Assuta Medical Centers in the period from September 2011 to February 2016. Medical history, clinical and neurological findings, pathological diagnoses, SRS variables, complications, and follow-up data were collected and analyzed. Local control rates were calculated, and local treatment failure cases were qualitatively studied. RESULTS One hundred treatment sessions were performed for 118 lesions at 179 spinal levels in 80 patients. The complication rate was low and did not correlate with a learning curve. Mean follow-up time was 302 days, and the overall local control rate was 95%. The local control rate was dose dependent and increased from 87% (among 35 patients receiving a dose of 16 Gy) to 97% (among 65 patients receiving a dose of 18 Gy). The 6 treatment failure cases are discussed in detail. CONCLUSIONS Spinal radiosurgery is a safe and effective treatment. Comprehensive education of the treating team and continuous communication are essential to limit the effects of the learning curve on outcome.

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40-year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in England and Wales, 1971–2011: a population-based study

Cited by 385 publications

References 21 publications

Factors in Removing Job Restrictions for Cancer Survivors in the United Kingdom Royal Air Force

Factors in Removing Job Restrictions for Cancer Survivors in the United Kingdom Royal Air Force

Improving early diagnosis of symptomatic cancer

Spine radiosurgery: lessons learned from the first 100 treatment sessions

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