40 Effect of hydroquinone on the synthesis of phaeomelanins

Harmand, Marie‐Françoise; Naji, Amel Mohson; Gonfrier, P.

doi:10.1007/bf00438212

Cell Biol Toxicol

1996

DOI: 10.1007/bf00438212

|View full text |Cite

40 Effect of hydroquinone on the synthesis of phaeomelanins

Marie‐Françoise Harmand

Amel Mohson Naji²,

P. Gonfrier³

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2000

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In culture, melanocytes obtained from eumelanic skin become phaeomelanic (Hunt et al, 1995). After irradiation, pheomelanogenesis is inhibited and eumelanogenesis is stimulated (Harmand et al, 1996), but after a single dose exposure no melanogenesis is induced in low phototype melanocytes (Barker et al, 1995).…”

mentioning

confidence: 99%

Studies on Epidermis Reconstructed with and without Melanocytes: Melanocytes Prevent Sunburn Cell Formation but not Appearance of DNA Damaged Cells in Fair-Skinned Caucasians

Cario‐André¹,

Pain²,

Taı̈eb³

et al. 2000

Journal of Investigative Dermatology

View full text Add to dashboard Cite

To assess the photoprotective role of melanocytes in the epidermis, we studied the effects of ultraviolet B on an epidermis reconstructed with and without melanocytes. To address more specifically the role of melanin in fair-skinned individuals, experiments were done with cells obtained from human skin of low phototypes (II-III). To study the effect of constitutive melanin and possibly that of newly synthesized melanin precursors, a single dose of ultraviolet B (0.10 or 0.15 J per cm2, corresponding to a 4-5 minimal erythema dose in vivo) was administered to reconstructs and the effects were monitored over the first 24 h. When reconstructs with and without melanocytes were compared, no difference was found for DNA damage/repair assessed with antibodies to cyclobutane pyrimidine dimers and 6-4 photoproducts. More necrotic/apoptotic cells, however, were noted 24 h following ultraviolet B irradiation in reconstructs lacking melanocytes. Twenty-four hours following ultraviolet B irradiation the number of necrotic/apoptotic cells and the number of cyclobutane pyrimidine dimer positive cells was coarsely concentration-dependent. The number of cyclobutane pyrimidine dimer positive cells, however, was independent of the type of reconstruct used (with/without melanocytes). In conclusion, low phototype melanocytes seem to protect epidermal basal cells against ultraviolet B-induced apoptosis/necrosis and may preserve the overall integrity of the epidermis after ultraviolet B irradiation. On the contrary, such melanocytes do not seem to have a protective role against DNA damage and may not prevent cancer.

show abstract

mentioning

confidence: 99%

Studies on Epidermis Reconstructed with and without Melanocytes: Melanocytes Prevent Sunburn Cell Formation but not Appearance of DNA Damaged Cells in Fair-Skinned Caucasians

Cario‐André¹,

Pain²,

Taı̈eb³

et al. 2000

Journal of Investigative Dermatology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

40 Effect of hydroquinone on the synthesis of phaeomelanins

Cited by 1 publication

References 0 publications

Studies on Epidermis Reconstructed with and without Melanocytes: Melanocytes Prevent Sunburn Cell Formation but not Appearance of DNA Damaged Cells in Fair-Skinned Caucasians

Studies on Epidermis Reconstructed with and without Melanocytes: Melanocytes Prevent Sunburn Cell Formation but not Appearance of DNA Damaged Cells in Fair-Skinned Caucasians

Contact Info

Product

Resources

About