40 Does nasal provocation play a role in the diagnosis of ragweed induced allergic rhinitis?

Small, Peter; Biskin, N; Barrett, Doreen

doi:10.1016/0091-6749(91)91323-l

Cited by 1 publication

(5 citation statements)

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“…Case‐control studies compared either AR vs NAR populations (n = 21), AR vs healthy controls (n = 10), or NAR vs healthy control (n = 2) . The case series assessed either AR‐only (n = 12) or NAR‐only (n = 1) populations. There were 43 studies that involved patients with AR and 24 studies that involved patients with NAR .…”

Section: Resultsmentioning

confidence: 99%

“…The case series assessed either AR‐only (n = 12) or NAR‐only (n = 1) populations. There were 43 studies that involved patients with AR and 24 studies that involved patients with NAR . There were 6 studies that involved exclusively children under 16 years of age.…”

Section: Resultsmentioning

confidence: 99%

“…NAPT was performed with either dust (n = 22), grass/tree pollens (n = 13), or Alternaria mold (n = 2) . Three studies used allergens dependent on the patient's most likely sensitization .…”

Section: Resultsmentioning

confidence: 99%

“…The measurement tools used to determine nasal reactivity were either subjective (n = 12), objective (n = 9), or a combination of both (n = 21) . The outcome measures were unclear for 4 studies .…”

Section: Resultsmentioning

confidence: 99%

“…Objective assessments utilized either acoustic rhinometry, rhinomanometry, or PNIF . A combined scoring system of both induced symptoms and severity of increased nasal airway resistance from rhinomanometry was also used . Among these, only 16 studies fulfilled the Spanish recommendation for positivity criteria on NAPT and 6 studies fulfilled the EAACI/GA 2 LEN 2007 recommendation for positivity criteria …”

Section: Resultsmentioning

confidence: 99%

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Positive allergen reaction in allergic and nonallergic rhinitis: a systematic review

Hamizan

Rimmer

Alvarado

et al. 2017

Int Forum Allergy Rhinol

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Background:The diagnosis of allergic rhinitis (AR) is based on cutaneous and serological assessment to determine immunoglobulin E (IgE)-mediated disease. However, discrepancies between these tests and nasal provocation exist. Patients diagnosed as non-allergic rhinitis (NAR) but with positive nasal allergen provocation test (NAPT) may represent a local allergic condition or entopy, still suitable to allergy interventions. The objective of this study was to determine the frequency of nasal reactivity toward allergens among AR and NAR patients, and to describe the diagnostic characteristics of NAPT methodologies.Methods: EMBASE (1947-) and Medline (1946-) were searched until December 8, 2015. A search strategy was used to identify studies on AR or NAR patients subjected to diagnostic local nasal provocation. All studies providing original NAPT data among the AR or NAR population were included. Meta-analysis of proportion data was presented as a weighted probability % (95% confidence interval [CI]). Results:The search yielded 4504 studies and 46 were included. The probability of nasal allergen reactivity for the AR population was 86.3% (95% CI, 84.4 to 88.1) and in NAR was 24.7% (95% CI, 22.3 to 27.2). Reactivity was high with pollen for both AR 97.1% (95% CI, 94.2 to 99.2) and NAR 47.5% (95% CI, 34.8 to 60.4), and lowest with dust for both AR 79.1% (95% CI, 76.4 to 81.6) and NAR 12.2% (95% CI, 9.9 to 14.7). NAPT yielded high positivity when defined by subjective end-points: AR 91.0% (95% CI, 86.6 to 94.8) and NAR 30.2% (95% CI, 22.9 to 37.9); and lower with objective endpoints: AR 80.8% (95% CI, 76.8 to 84.5) and NAR 14.1% (95% CI, 11.2 to 17.2). Conclusion:Local allergen reactivity is demonstrated in 26.5% of patients previously considered non-allergic. Similarly, AR, when defined by skin-prick test (SPT) or serum specific IgE (sIgE), may lead to 13.7% of patients with inaccurate allergen sensitization or non-allergic etiologies. C 2017 ARS-AAOA, LLC. How to Cite this Article: Hamizan AW, Rimmer J, Alvarado R, et al. Positive allergen reaction in allergic and nonallergic rhinitis: a systematic review. Int Forum Allergy Rhinol. 2017;7:868-877.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…NAPT was performed with either dust (n = 22), grass/tree pollens (n = 13), or Alternaria mold (n = 2) . Three studies used allergens dependent on the patient's most likely sensitization .…”

Section: Resultsmentioning

confidence: 99%