40  Dietary Saccharomyces cerevisiae fermentate affects mucosal immunity in young stress-challenged horses in training

IntroductionNutritional and environmental stressors can disturb the gut microbiome of horses which may ultimately decrease their health and performance. We hypothesized that supplementation with a yeast-derived postbiotic (Saccharomyces cerevisiae fermentation product-SCFP) would benefit horses undergoing an established model of stress due to prolonged transportation.MethodsQuarter horses (n = 20) were blocked based on sex, age (22 ± 3 mo) and body weight (439 ± 3 kg) and randomized to receive either a basal diet of 60% hay and 40% concentrate (CON) or the basal diet supplemented with 21 g/d Diamond V TruEquine C (SCFP; Diamond V, Cedar Rapids, IA) for 60 days. On day 57, horses were tethered with their heads elevated 35cm above wither height for 12 h to induce mild upper respiratory tract inflammation. Fecal samples were collected at days 0, 28, and 56 before induction of stress, and at 0, 12, 24, and 72 h post-stress and subjected to DNA extraction and Nanopore shotgun metagenomics. Within sample (alpha) diversity was evaluated by fitting a linear model and between sample (beta) diversity was tested with permutational ANOVA.ResultsThe SCFP stabilized alpha diversity across all time points, whereas CON horses had more fluctuation (P < 0.05) at 12, 24, and 72 h post-challenge compared to d 56. A significant difference between CON and SCFP was observed at 0 and 12 h. There was no difference in beta-diversity between SCFP and CON on d 56.DiscussionTaken together, these observations led us to conclude that treatment with SCFP resulted in more robust and stable microbial profiles in horses after stress challenge.

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Saccharomyces cerevisiae fermentation product improves robustness of equine gut microbiome upon stress

Ganda

Chakrabarti²,

Sardi³

et al. 2023

Front. Vet. Sci.

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40  Dietary Saccharomyces cerevisiae fermentate affects mucosal immunity in young stress-challenged horses in training

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Saccharomyces cerevisiae fermentation product improves robustness of equine gut microbiome upon stress

Saccharomyces cerevisiae fermentation product improves robustness of equine gut microbiome upon stress

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40 Dietary Saccharomyces cerevisiae fermentate affects mucosal immunity in young stress-challenged horses in training

Cited by 1 publication

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Saccharomyces cerevisiae fermentation product improves robustness of equine gut microbiome upon stress

Saccharomyces cerevisiae fermentation product improves robustness of equine gut microbiome upon stress

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40  Dietary Saccharomyces cerevisiae fermentate affects mucosal immunity in young stress-challenged horses in training