4 Viruses and bone marrow failure

Kurtzman, Gary J.; Young, Neal S.

doi:10.1016/s0950-3536(89)80007-1

Cited by 44 publications

(28 citation statements)

References 96 publications

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“…The target cells of PVB19 are erythroid progenitor cells [23][24][25]. Other progenitor cells may also be affected by inefficient viral replication [26]. Most PVB19 infected patients and experimental infections in normal volunteers showed transient falls in neutrophil and platelet counts [1,27,28].…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of severe aplastic anemia associated with human parvovirus B19 and Epstein‐Barr virus in a healthy subject with allo‐BMT

et al. 2001

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Several reports have noted pancytopenia associated with Human parvovirus B19 (PVB19)or Ebstein-Barr virus (EBV) infections in patients who have no history of immunodeficiency. To our knowledge, we report the first case of severe aplastic anemia associated with both EBV and PVB19 infections in a previously healthy 22-year-old man. He was admitted to our hematology service due to anemia and thrombocytopenia. He had no symptoms or signs of infections of these viruses. His bone marrow biopsy revealed a hypocellular marrow. Specific IgM and IgG antibodies to EBV and PVB19 were elevated. EBV and PVB19 virus genomes were detected by PCR in the bone marrow nucleated cells and the peripheral blood lymphocytes. Two months after treatment with prednisone, acyclovir, and intravenous immune globulin (IVIg), the genomes of both these viruses disappeared. However, his transfusion requirement for platelet suspensions and packed red blood cells persisted. The patient underwent allogeneic bone marrow transplant (allo-BMT) and has had an enduring complete hematological response for 8 months. Am.

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Section: Discussionmentioning

confidence: 99%

Successful treatment of severe aplastic anemia associated with human parvovirus B19 and Epstein‐Barr virus in a healthy subject with allo‐BMT

et al. 2001

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“…The frequency ofEB virus-caused aplastic anemia is low (3,4); EB virus DNAand protein were detected in only 1 of 40 patients with aplastic anemia studied retrospectively (4). The effect of viral infection on the suppressed hematopoiesis in patients with aplastic anemia is not fully understood (3,4). While the B cells are the recognized target ofEB virus infection, other cells mayalso harbor this virus (e.g., nasopharyngeal epithelial cells).…”

Section: Discussionmentioning

confidence: 99%

“…While the B cells are the recognized target ofEB virus infection, other cells mayalso harbor this virus (e.g., nasopharyngeal epithelial cells). Somehematopoietic cells may also be infected by EB virus (3,4,12). EB virus nuclear antigen (EBNA) is detected by immunofluorescence and EB virus DNAis detected by in situ hybridization in B cell-depleted bone marrow cells (3 , 4).…”

Section: Discussionmentioning

confidence: 99%

“…However, most cases are idiopathic (1). The viruses which can induce aplastic anemia include hepatitis virus, cytomegalovirus, Epstein-Barr (EB) virus, human immunedeficiency virus, and parvovirus B19 (2,3). However, most cases are diagnosed retrospectively based on indirect evidence such as the clinical manifestations, change in biochemistry, and rise in the levels of antibodies to the virus.…”

Section: Introductionmentioning

confidence: 99%

“…However, most cases are diagnosed retrospectively based on indirect evidence such as the clinical manifestations, change in biochemistry, and rise in the levels of antibodies to the virus. Aplastic anemia caused by EB virus remains rare (3,4). It occurs even in healthy individuals after the clinical course of infectious mononucleosis; the prognosis of patients with aplastic anemia caused by EB virus is not necessarily poor (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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Fatal Aplastic Anemia Caused by Epstein-Barr Virus Infection after Autologous Bone Marrow Transplantation for Non-Hodgkin Malignant Lymphoma.

et al. 1994

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Wereport a case of severe and fatal aplastic anemia during an episode of infectious mononucleosis caused by Epstein-Barr (EB) virus infection. The 13-year-old female patient had shown normal hematological findings and had previously undergone repeated chemotherapy and autologous bone marrowtransplantation for refractory non-Hodgkin malignant lymphoma(NHL). She was probably in an immuno-suppressed condition prior to this episode of infection. The possible causal relationship of the EB virus infection in the pathogenesis ofaplastic anemia was documented by the clinical course, demonstration ofEB virus genomein the bone marrow cells, and an elevated plasma interferon (IFN)-y level.

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Hepatitis C virus-induced leuko-thrombocytopenia and haemolysis

et al. 1997

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Hepatitis C virus (HCV) has been recognized as the cause of thrombocytopenia occurring in patients with chronic hepatitis C, possibly through autoimmune mechanisms. A patient is described with B cell chronic lymphocytic leukaemia, presenting with a marked leuko-thrombocytopenia and an associated mild haemolysis secondary to HCV infection, in the absence of clinical and biochemical signs of hepatitis. Anti-HCV antibodies were detected in the serum both by ELISA and RIBA but not 2 months before the onset of cytopenia. The presence of HCV RNA was documented both in the peripheral blood mononuclear cells and in the bone marrow by reverse transcriptase polymerase chain reaction of the 5' untranslated region of the viral genome. Of interest, HCV RNA was also found in the serum, showing that viraemia was associated with the presence of circulating anti-HCV antibodies. HCV genotyping, performed by PCR amplification of the core region, revealed the presence of an unclassifiable genotype. The hypothetical mechanisms leading to HCV-induced cytopenia in this patient are briefly discussed. Treatment with corticosteroids was effective in controlling blood cell counts, without increasing viraemia and deterioration of liver disease. HCV infection should be considered in the differential diagnosis of possible causes of cytopenia, mainly in immunosuppressed patients, even in absence of clinical and biochemical signs of hepatitis.

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4 Viruses and bone marrow failure

Cited by 44 publications

References 96 publications

Successful treatment of severe aplastic anemia associated with human parvovirus B19 and Epstein‐Barr virus in a healthy subject with allo‐BMT

Successful treatment of severe aplastic anemia associated with human parvovirus B19 and Epstein‐Barr virus in a healthy subject with allo‐BMT

Fatal Aplastic Anemia Caused by Epstein-Barr Virus Infection after Autologous Bone Marrow Transplantation for Non-Hodgkin Malignant Lymphoma.

Hepatitis C virus-induced leuko-thrombocytopenia and haemolysis

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