DOI: 10.1002/chin.200740126
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Michel Boulouard, Pascale Schumann-Bard, Sabrina Butt-Gueulle et al.

Abstract: Pyrazole derivatives R 0180 4-Substituted Indazoles as New Inhibitors of Neuronal Nitric Oxide Synthase. -Halogenated indazoles such as (III) are obtained by diazotization of methylanilines (I), followed by cyclization of the resulting diazonium tetrafluoroborate salts (II) through promotion of potassium acetate and a crown ether. Position 4 of the new inhibitors seems to be as important as position 7 to confer inhibitory properties against NOS activity. The importance of position 4 is further demonstrated by…

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