Michel Boulouard, Pascale Schumann-Bard, Sabrina Butt-Gueulleet al.
Pyrazole derivatives R 0180 4-Substituted Indazoles as New Inhibitors of Neuronal Nitric Oxide Synthase. -Halogenated indazoles such as (III) are obtained by diazotization of methylanilines (I), followed by cyclization of the resulting diazonium tetrafluoroborate salts (II) through promotion of potassium acetate and a crown ether. Position 4 of the new inhibitors seems to be as important as position 7 to confer inhibitory properties against NOS activity. The importance of position 4 is further demonstrated by…
scite is a Brooklyn-based startup that helps researchers better discover and evaluate scientific articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by researchers from dozens of countries and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.