Abstract:(−)-Pavidolide B is a complex
tetracyclic diterpenoid with seven contiguous stereocenters, and classical
total syntheses have recently been reported. In this work, an annulation strategy
of carbanion cascade reaction is formulated for accomplishing an asymmetric
total synthesis of (−)-pavidolide B in just 4 linear steps. The key reaction
is a tandem intramolecular Michael addition, which constructs two 5-membered
rings and five stereocenters in a highly selective fashion in one step. This
work represents one o… Show more
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