4 Plasma for Therapeutic Use

Schlenke, Peter; Sibrowski, W.

doi:10.1159/000268060

Cited by 7 publications

(1 citation statement)

References 57 publications

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“…The preparation of human plasma products follows strict guidelines from the point of donor selection to product processing. Fresh frozen plasma (FFP) is produced from whole blood donations which undergo centrifugation, or by apheresis [1]. Leukocyte depletion is either achieved by filtration during whole blood processing or integrated in the apheresis process.An anticoagulant solution is always added during the collection of FFP.…”

Section: Plasma Preparations For Transfusionmentioning

confidence: 99%

Plasma Transfusion Practice in Adult Surgical Patients: Systematic Review of the Literature

Adam

Fischer

2020

Transfus Med Hemother

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Background: Plasma transfusions are most commonly used therapeutically for bleeding or prophylactically in nonbleeding patients prior to invasive procedures or surgery. Although plasma transfusions generally seem to decline, plasma usage for indications that lack evidence of efficacy prevail. Summary: There is wide international, interinstitutional, and interindividual variance regarding the compliance with guidelines based on published references, supported by appropriate testing. There is furthermore a profound lack of evidence from randomized controlled trials comparing the effect of plasma transfusion with that of other therapeutic interventions for most indications, including massive bleeding. The expected benefit of a plasma transfusion needs to be balanced carefully against the associated risk of adverse events. In light of the heterogeneous nature of bleeding conditions and their rapid evolvement over time, fibrinogen and factor concentrate therapy, directed at specific phases of coagulation identified by alternative laboratory assays, may offer advantages over conventional blood product ratio-driven resuscitation. However, their outcome benefit has not been demonstrated in well-powered prospective trials. This systematic review will detail the current evidence base for plasma transfusion in adult surgical patients.

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Section: Plasma Preparations For Transfusionmentioning

confidence: 99%