4‐Picoline‐2,2′:6′,2″‐terpyridine‐platinum(II) — A potent intercalator of DNA

Platinum complexes of terpyridine: Interaction and reactivity with biomolecules

“…The dicationic pyridine complex [Pt(terpy)(4-picoline)] 2+ binds very strongly to DNA via intercalation, as evidenced by gel electrophoresis of products and changes to UV-vis absorption spectrum and DNA melting temperature [22,23]. For r f < 0.16, changes in the CD spectrum of poly[d(A-T)] 2 DNA were used to determine a binding constant of K = (1.8 ± 0.5) × 10 7 M −1 and a binding site size of every 4 base pairs, suggesting that the dicationic nature of this intercalator limits near-neighbor binding mode.…”

The Design and Synthesis of Bis-[4′-Azido-2,2′:6′,2″-Terpyridine Platinum(II)] Complexes with Rigid and Extended Linkers for Studying the Topology of DNA by Photoaffinity Labeling

“…We have shown that 2,2Ј:6Ј,2Љ-terpyridine platinum(II) 4-picoline complexes are potent intercalators of DNA and have selected this moiety for the intercalator groups (1). The linkers provide the fourth ligand in the 2,2Ј:6Ј,2Љ-terpyridine platinum(II) complexes and have 4-substituted pyridine groups at each end.…”

Metal-Based Biologically Active Agents: Synthesis, Characterization, Antimicrobial and Biochemical Studies of Mixed Ligand Complexes

“…Under the same set of conditions, addition of metal complexes increased T m (±1°C) by 4°C, 6°C and 5°C, respectively, which indicate that these compounds stabilize the double helix of DNA. This method is easy to identify when more than one transition occurs (McCoubery et al, 1996). These variations in T m of calf thymus DNA strongly supported the intercalation of metal complex into the double helix DNA.…”