4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity

Abstract

Three new 4-phenylcoumarins, mesuaferlinns A-C (1-3), together with ten known 4-phenylcoumarins, 4-13, were isolated from the branches and leaves of Mesua ferrea Linn. (Clusiaceae). The structure of compounds 1-3 were determined on the basis of spectroscopic methods including extensive analysis of NMR and mass spectroscopic data. Ten 4-phenylcoumarins were tested for their cytochrome P450 family 1 enzymes (CYP 1A1, CYP 1A2, and CYP 1B1) inhibitory effects. Compounds 5 and 10 were found to be the most potent two CYP1B1 inhibitors with inhibitory viabilities values of 56.64% and 47.46%.