4-phenyl butyric acid improves hepatic ischemia/reperfusion and affects gene expression of ABC transporter Abcc5 in rats
Bülent Barış Güven,
Alpaslan Tanoglu,
Fatih Ozcelik
et al.
Abstract:Aim To assess the effects of 4-phenyl butyric acid (PBA) on oxidative stress, inflammation, liver histology, endoplasmic (ER) reticulum stress, and the expression levels of ATP-binding cassette transporter family members in a hepatic ischemia-reperfusion (IR) model. Methods Thirty-five rats were randomly divided into five groups: sham, IR, IR + 100 mg kg −1 PBA, IR + 200 mg kg −1 PBA, and IR + placebo. After sacrifice, we assessed serum biochemical variables, myeloperoxidase (MPO), malondialdehyde (MDA), total… Show more
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