4-Nonylphenol reduces cell viability and induces apoptosis and ER-stress in a human epithelial intestinal cell line

Lepretti, Marilena; Paolella, Gaetana; Giordano, D.; Marabotti, Anna; Gay, Françoise; Capaldo, Anna; Esposito, Carla; Caputo, Ivana

doi:10.1016/j.tiv.2015.04.022

Cited by 33 publications

(17 citation statements)

References 54 publications

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“…They are not biodegraded and persists for a long time in activated sludges and effluents of wastewater treatment plants (Krupi nski et al 2014). Nonylphenols have been identified as endocrine disruptors, in animals and humans (Soto et al 1991), are cytotoxic, induce apoptosis (Lepretti et al 2015) and alter the immune response of lymphocytes and macrophages in humans (Lee et al 2017). The microbial consortium NP-M2, obtained by culture enrichment from activated sludge samples collected from a wastewater treatment plant, was able to degrade almost 90% (4Á1 mmol l À1 ) of NP present as sole carbon source, after 8 days of cultivation.…”

Section: Alicycliphilus Participation In Xenobiotics Bioremediation Smentioning

confidence: 99%

Alicycliphilus : current knowledge and potential for bioremediation of xenobiotics

Solís-González

Loza-Tavera

2019

J Appl Microbiol

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Summary Alicycliphilus is a promising candidate for participating in the development of novel xenobiotics bioremediation processes. Members of the Alicycliphilus genus are environmental bacteria mostly found in polluted sites such as landfills and contaminated watercourses, and in sewage sludges from wastewater treatment plants. They exhibit a versatile metabolism and the ability to use oxygen, nitrate and chlorate as terminal electron acceptors, which allow them to biodegrade xenobiotics under oxic or anoxic conditions. Pure cultures of Alicycliphilus strains are able to biodegrade some pollutants such as industrial solvents (acetone, cyclohexanol and N‐methylpyrrolidone), aromatic hydrocarbons (benzene, toluene and anthracene), as well as polyurethane varnishes and foams, and they can even transform Cr(VI) to Cr(III). In addition, Alicycliphilus has also been identified in bacterial communities involved in wastewater treatment plants for denitrification, and the degradation of emerging pollutants such as triclosan, nonylphenol, N‐heterocyclic aromatic compounds (indole and quinoline), and antibiotics (tetracycline and oxytetracycline). This work summarizes the current knowledge on the Alicycliphilus genus, describing its different metabolic characteristics, focusing on its xenobiotic biodegradation abilities and examining the distinct pathways and molecular bases that sustain them. We also discuss the progress made in genetic manipulation and ‘omics’ analyses, as well as Alicycliphilus participation in novel bioremediation strategies.

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Section: Alicycliphilus Participation In Xenobiotics Bioremediation Smentioning

confidence: 99%

Alicycliphilus : current knowledge and potential for bioremediation of xenobiotics

Solís-González

Loza-Tavera

2019

J Appl Microbiol

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“…NP activates endoplasmic reticulum stress response, Fas/FasL, MAPKs, Akt and JNK signaling pathways, resulting in changes in cell survival, cell cycle progression and apoptosis (Choi et al 2014;Duan et al 2016c;Lepretti et al 2015;Liu et al 2015;Yao et al 2005). Importantly, our previous study outlined that NP treatment triggers Sertoli cell (SC) autophagy, probably through the ROS-mediated AMPK-mTOR pathway (Duan et al 2016c).…”

Section: Introductionmentioning

confidence: 98%

“…4-Nonylphenol (NP) is a primary breakdown product of nonylphenol ethoxylate (NPE), nonionic surfactant widely employed in domestic, industrial and agricultural applications (Lepretti et al 2015;Liu et al 2015). NP has been detected in surface water, groundwater, atmosphere, soils and human foodstuffs in various countries around the world, suggesting widespread human exposure (Vidal-Linan et al 2015).…”

Section: Introductionmentioning

confidence: 99%

4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells

Duan

Quan

et al. 2017

Toxicology Letters

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The estrogenic chemical 4-nonylphenol (NP) is known to impair testicular devolopment and spermatogenesis in rodents. The objective of this study was to explore the effects of NP on autophagy induction and AMPK-mTOR signaling pathway in Sertoli cells (SCs), which are the "nursemaid cells" for meiosis of spermatocytes. In this study we exposed 7-week-old male rats to NP by intra-peritoneal injection at 0, 20, 50 or 100 mg/kg body weight/2 days for 20 consecutive days. Our results showed that exposure to NP dose-dependently induces the formation of autophagosomes in SCs, increases the expression of Beclin-1, the conversion of LC3-I to LC3-II and the mRNA expression of Atg3, Atg5, Atg7 and Atg12 in testis, and these effects are concomitant with the activation of AMPK, and the suppression of TSC2-mTOR-p70S6K/4EBP1 signaling cascade in testis. Furthermore, 10 µM Compound C or AMPKα1 siRNA pre-treatment effectively attenuated autophagy and reversed AMPK-mTOR-p70S6K/4EBP1 signaling in NP-treated SCs. Co-treatment with 1 mM AICAR remarkably strengthened NP-induced autophagy and mTOR inhibition in SCs. Together, these data suggest that NP stimulates Sertoli cell autophagy and inhibits mTOR-p70S6K/4EBP1 activity through AMPK activation, which is the potential mechanism responsible for the regulation of testis function and differentiation following NP exposure.

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“…APs are exposed to humans through ingestion of contaminated food or water, and dermal absorption. [5][6][7][8][9][10] Because of these reasons, AP is one of the most dangerous toxicants. [5][6][7][8][9][10] Because of these reasons, AP is one of the most dangerous toxicants.…”

Section: Introductionmentioning

confidence: 99%

An Electronic‐structure Informatics Study on the Toxicity of Alkylphenols toTetrahymena pyriformis

Sugimoto

Manggara

Yoshida

et al. 2020

Molecular Informatics

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Alkylphenols (APs) dissolved in water are known to be toxic to animals including humans. In this study, regression models describing the toxicity of the 33 AP molecules were investigated for reproducing and thereby making it possible to predict a quantitative structureactivity relationship (QSAR). For this purpose, we tried to derive regression models for the experimental IGC 50 (growth inhibition concentration at 50 %) to Tetrahymena pyriformis by using various descriptor sets consisting of electronic and shape descriptors. By applying the multiple linear regression (MLR) analysis, it was successful to derive a quantitative regression model for the IGC 50 values. In this analysis, the size parameters of the molecules were found important, suggesting that bulky molecules should be less toxic. We could also obtain, when the size descriptors were excluded, an MLR model indicating that the electron affinity (EA) should be important, which is consistent with the previous QSAR studies. Through the correlation analysis among the descriptors, it was shown that, in the present set of molecules, EA and a size parameter are highly correlated. Since EA was calculated to be negative, indicating that the related process would be energetically unfavourable, it was concluded that the size of the molecules should be a dominant factor determining IGC 50 . This implies that a molecular recognition process would play a critical role in the mode of action for the toxicity.

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4-Nonylphenol reduces cell viability and induces apoptosis and ER-stress in a human epithelial intestinal cell line

Cited by 33 publications

References 54 publications

Alicycliphilus : current knowledge and potential for bioremediation of xenobiotics

Alicycliphilus : current knowledge and potential for bioremediation of xenobiotics

4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells

An Electronic‐structure Informatics Study on the Toxicity of Alkylphenols toTetrahymena pyriformis

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