4-Nitro-propranolol selectively inhibits the positive chronotropic effect induced by 6-nitrodopamine in the rat isolated right atrium
Denis Lima Oliveira,
Vinicius Francisco Cardoso,
Jose Britto-Júnior
et al.
Abstract:6-Nitrodopamine (6-ND) is released from isolated atria of rabbit, rat and mice and has significant positive chronotropic action. The positive chronotropic effect induced by 6-ND is selectively blocked by β1-adrenoceptor antagonists at concentrations that do not affect the positive chronotropic effect induced by dopamine, noradrenaline, and adrenaline. Here the effects of propranolol, 4-NO2-propranolol and 7-NO2-propranolol were investigated in the rat isolated right atrium. The right atrium was mounted between… Show more
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