4-month-old boy coinfected with COVID-19 and adenovirus

Danley, Kelsey; Kent, Paul

doi:10.1136/bcr-2020-236264

Cited by 13 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, coinfection of adenovirus and SARS‐CoV‐2 has been reported in a limited number of patients over 15 years of age and adults 20,50,51 . A case report of adenovirus coinfection with SARS‐CoV‐2 in a 4‐month‐old infant negated the misconception regarding the unlikelihood of adenovirus coinfection in infants, indicating that complete screening for COVID‐19 in addition to other virus infections, in this particular case, significantly reduced the risk of being an asymptotic carrier 80 …”

Section: Introductionmentioning

confidence: 94%

Viral coinfections in COVID‐19

Aghbash

Eslami

Shirvaliloo

et al. 2021

Journal of Medical Virology

View full text Add to dashboard Cite

The most consequential challenge raised by coinfection is perhaps the inappropriate generation of recombinant viruses through the exchange of genetic material among different strains. These genetically similar viruses can interfere with the replication process of each other and even compete for the metabolites required for the maintenance of the replication cycle. Due to the similarity in clinical symptoms of most viral respiratory tract infections, and their coincidence with COVID‐19, caused by SARS‐CoV‐2, it is recommended to develop a comprehensive diagnostic panel for detection of respiratory and nonrespiratory viruses through the evaluation of patient samples. Given the resulting changes in blood markers, such as coagulation factors and white blood cell count following virus infection, these markers can be of diagnostic value in the detection of mixed infection in individuals already diagnosed with a certain viral illness. In this review, we seek to investigate the coinfection of SARS‐CoV‐2 with other respiratory and nonrespiratory viruses to provide novel insights into the development of highly sensitive diagnostics and effective treatment modalities.

show abstract

Section: Introductionmentioning

confidence: 94%

Viral coinfections in COVID‐19

Aghbash

Eslami

Shirvaliloo

et al. 2021

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…The most important finding of the present study is that we described an example of co-infection with SARS-CoV-2 and HAdV among some pneumonia patients with obvious epidemiological relationship. Previous studies have reported sporadic cases caused by co-infections of SARS-CoV-2 with other pathogens, including influenza A virus, respiratory syncytial virus, metapneumovirus, rhinovirus, and HAdV (8)(9)(10)(11)(12). The detection of SARS-CoV-2 co-infection with other respiratory viruses is difficult.…”

Section: Discussionmentioning

confidence: 99%

“…SARS-CoV-2 co-infection alongside other pathogens have been reported, including occasional co-infections involving human adenovirus (HAdV) and SARS-CoV-2. However, reports of co-infections are rare (8)(9)(10)(11)(12). Moreover, little is known regarding whether SARS-CoV-2 co-infections are transmitted between individuals at rates capable of causing clusters of acute respiratory infections.…”

Section: Introductionmentioning

confidence: 99%

Pneumonia Patients Caused by Co-infection With SARS-CoV-2 and Human Adenovirus in China

Qiu¹,

Li³

et al. 2021

Front. Med.

View full text Add to dashboard Cite

Objectives: To data, no patients with obvious epidemiological relationship co-infected with SARS-CoV-2 and other pathogens have been reported. Here, we investigated 10 patients caused by co-infection with SARS-CoV-2 and human adenovirus (HAdV), resulting in third-generation transmission.Materials and Methods: From Jan 15, 2020, we enrolled 10 patients with pneumonia in Hunan Province, China. Epidemiological, clinical, and laboratory investigation results from these patients were analyzed. An epidemiological investigation was performed to assess whether patient infections were linked using conventional methods and metagenomic sequencing.Results: The presence of co-infection with SARS-CoV-2 and HAdV was determined via RT-PCR and metagenomic sequencing. Phylogenetic analysis revealed that SARS-CoV-2 and HAdV genomes clustered together, with similar genetic relationships. The first patient likely became co-infected during meetings or travel in Wuhan. The patient transmitted the virus via dinners and meetings, which resulted in four second-generation cases. Then, a second-generation case transmitted the virus to her family members or relatives via presymptomatic transmission.Conclusions: This study described an example of co-infection with SARS-CoV-2 and HAdV in pneumonia patients, which caused third-generation cases and inter-regional transmission via meetings, household interactions, and dinner parties. We also observed the persistent and presymptomatic transmission of co-infection, which has the potential to make the continued control of the COVID-19 pandemic challenging. Continuous surveillance is needed to monitor the prevalence, infectivity, transmissibility, and pathogenicity of SARS-CoV-2 co-infection with other pathogens to evaluate its real risk.

show abstract

“…Childhood infection with SARS-CoV-2 may range from an asymptomatic individual to upper respiratory tract infection, skin rashes, pneumonia, gastrointestinal upset, acute respiratory distress syndrome, nervous system involvement, rhabdomyolysis, and the newly recognized Kawasaki disease like presentation of Multisystem Inflammatory Syndrome in Children [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Studies have also demonstrated prolonged fecal shedding of SARS-CoV-2 virus in children who have apparently recovered from COVID-19, raising the possibility of children acting as major sources of disease spread among communities [17]. Moreover, there are reports of children being coinfected with SARS-CoV-2 along with other viruses, which may have caused the presence of COVID-19 to be overlooked and subsequent isolation precautions neglected [8].…”

Section: Introductionmentioning

confidence: 99%

A Clinical Profile of Pediatric COVID-19 Testing in the Emergency Department, Dubai, United Arab Emirates

Mir

Saleh

2022

International Journal of Pediatrics

View full text Add to dashboard Cite

Background. The COVID-19 pandemic marked a health and economic crisis of massive proportions. In its early months, literature was centered on adult medical and critical care. As time progressed, international reports of COVID-19 infection in children steadily grew; however, data on disease features in the United Arab Emirates’ pediatric population was noticeably lagging. Method. The presented research was conducted at Latifa Women and Children Hospital Emergency Department to ascertain an association between a child’s presenting features and basic investigations to a subsequent positive COVID-19 test result. Data was collected via electronic medical records and statistical analysis performed with SPSS version 22.0. Results. A total of four hundred and five (405) patients were analyzed, with 32 (8%) being COVID-19 positive on initial testing in emergency department. There is a statistically significant correlation ( p < 0.05 ) between testing positive for COVID-19 infection and history of exposure to COVID-19-positive individuals; the presence of runny nose, cough, poor feeding, and abdominal pain with reassuring physical examination findings; and predominantly normal reports of basic blood investigations and chest X-ray images. Conclusion. This research demonstrates that a minority of children tested for COVID-19 in the initial wave of the pandemic tested positive. A significant proportion of COVID-19-positive pediatric patients exhibit history of exposure to COVID-19-positive individuals; the presence of runny nose, cough, poor feeding, and abdominal pain; normal physical examination; normal basic blood investigations and chest X-ray findings.

show abstract

4-month-old boy coinfected with COVID-19 and adenovirus

Cited by 13 publications

References 16 publications

Viral coinfections in COVID‐19

Viral coinfections in COVID‐19

Pneumonia Patients Caused by Co-infection With SARS-CoV-2 and Human Adenovirus in China

A Clinical Profile of Pediatric COVID-19 Testing in the Emergency Department, Dubai, United Arab Emirates

Contact Info

Product

Resources

About