4-Methyl-N-{2-[(E)-3-oxo-3-phenylprop-1-en-1-yl]phenyl}benzenesulfonamide

Abstract

Key indicators: single-crystal X-ray study; T = 200 K; mean (C-C) = 0.004 Å; R factor = 0.057; wR factor = 0.154; data-to-parameter ratio = 18.7.In the title compound, C 22 H 19 NO 3 S, the terminal phenyl and methylphenyl rings are twisted by 37.35 (12) and 49.08 (13) , respectively, to the central benzene ring. In the crystal, molecules are linked by classical N-HÁ Á ÁO hydrogen bonds and weak C-HÁ Á ÁO hydrogen bonds into a three-dimensional supramolecular network. Related literature

Conformational Variability in Sulfonamide Chalcone Hybrids: Crystal Structure and Cytotoxicity

“…In sequence, crystal structure of two TSAHC analogs, which cytotoxicity is reported here (compounds 5 and 6), 26 were elucidated by our research group. Not so much similar to TSAHC and its analogs, all of them owing arylsulfonamide moiety attached in the 1-phenyl group from chalcone scaffold in the para-position, crystal structure of some other related compound with arylsulfonamide bonded in the ortho-position of either 1-phenyl (two compounds) 27,28 or 3-phenyl (six compounds) [29][30][31][32][33][34] ring from chalcone core has been also determined.…”