4-Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice

Jeong, Yongwoo; Bae, Ho Jung; Park, Keontae; Bae, Hyo Jeoung; Yang, Xingquan; Cho, Youngjin; Jang, Dae Sik; Ryu, Jong Hoon

doi:10.1016/j.jep.2021.114864

Cited by 15 publications

(6 citation statements)

References 52 publications

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“…Prior to investigating the effect of KRG on the immobilization-induced anxiety-like behaviors and its underlying mechanism(s), RRT was carried out to examine whether our experimental drugs, including KRG, could influence motor coordination in mice. The falling frequency in the control group appeared to be relative high, probably due to the short training period [ 30 ]. However, there were no significant changes in endurance time and falling frequency in all animal groups ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice

Bui

Nguyen²,

Thu³

et al. 2022

Journal of Ginseng Research

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Section: Resultsmentioning

confidence: 99%

Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice

Bui

Nguyen²,

Thu³

et al. 2022

Journal of Ginseng Research

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“…4-Methoxycinnamic acid is a natural phenolic acid with multiple effects, such as neuroprotection and cancer inhibition [ 42 ]. It was reported that 4-methoxycinnamic acid would be a potential candidate for the treatment of schizophrenia, because of reducing schizophrenic-like behavior in mice and having fewer adverse reactions [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Widely Targeted Metabolomics Reveals the Effects of Soil on the Metabolites in Dioscorea opposita Thunb.

et al. 2023

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Chinese yam (Dioscorea opposita Thunb. cv. Tiegun), a type of homologous medicinal plant, mainly grows in sandy soil (SCY) and loessial soil (LCY). However, the effects of the soil on the metabolites in SCY and LCY remain unclear. Herein, this study aims to comprehensively elucidate the metabolites in SCY and LCY. A UPLC-MS/MS-based, widely targeted metabolomics approach was adapted to compare the chemical composition of SCY and LCY. A total of 988 metabolites were detected, including 443 primary metabolites, 510 secondary metabolites, and 35 other compounds. Notably, 177 differential metabolites (classified into 12 categories) were identified between SCY and LCY; among them, 85.9% (152 differential metabolites) were upregulated in LCY. LCY significantly increased the contents of primary metabolites such as 38 lipids and 6 nucleotides and derivatives, as well as some secondary metabolites such as 36 flavonoids, 28 phenolic acids, 13 alkaloids, and 6 tannins. The results indicate that loessial soil can improve the nutritional and medicinal value of D. opposita.

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“…Previously, we have reported that aripiprazole can cause fine motor coordination deficits (Bae et al, 2023), probably, due to its partial agonism of dopamine D2 receptor (Kikuchi et al, 2021). Similarly, haloperidol can cause severe cataleptic behavior (Jeong et al, 2022). Fortunately, D‐pinitol did not show any motor dysfunction, one of severe adverse effects of conventional antipsychotics.…”

Section: Discussionmentioning

confidence: 99%

“…We generated a schizophrenia-like animal model by a single acute administration of MK-801 (0.2 mg/kg, i.p. ), according to previous studies (Jeong et al, 2022). D-Pinitol (30, 100, or 300 mg/kg, p.o.)…”

Section: Drug Administrationmentioning

confidence: 99%

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Effect of D‐pinitol on MK‐801‐induced schizophrenia‐like behaviors in mice

Kim,

Kong,

Kim

et al. 2023

Phytotherapy Research

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Schizophrenia is a chronic brain disorder characterized by positive symptoms (delusions or hallucinations), negative symptoms (impaired motivation or social withdrawal), and cognitive impairment. In the present study, we explored whether D‐pinitol could ameliorate schizophrenia‐like behaviors induced by MK‐801, an N‐methyl‐D‐aspartate receptor antagonist. Acoustic startle response test was conducted to evaluate the effects of D‐pinitol on sensorimotor gating function. Social interaction and novel object recognition tests were employed to measure the impact of D‐pinitol on social behavior and cognitive function, respectively. Additionally, we examined whether D‐pinitol affects motor coordination. Western blotting was conducted to investigate the mechanism of action of D‐pinitol. Single administration of D‐pinitol at 30, 100, or 300 mg/kg improved the sensorimotor gating deficit induced by MK801 in the acoustic startle response test. D‐Pinitol also reversed social behavior deficits and cognitive impairments induced by MK‐801 without causing any motor coordination deficits. Furthermore, D‐pinitol reversed increased expression levels of pNF‐kB induced by MK‐801 treatment and consequently increased expression levels of TNF‐α and IL‐6 in the prefrontal cortex. These results suggest that D‐pinitol could be a potential candidate for treating sensorimotor gating deficits and cognitive impairment observed in schizophrenia by down‐regulating transcription factor NF‐κB and pro‐inflammatory cytokines in the prefrontal cortex.

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4-Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice

Cited by 15 publications

References 52 publications

Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice

Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice

Widely Targeted Metabolomics Reveals the Effects of Soil on the Metabolites in Dioscorea opposita Thunb.

Effect of D‐pinitol on MK‐801‐induced schizophrenia‐like behaviors in mice

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