4-p-Anisyl-1,2′-diphenyl-3-p-tolyl-2′,3′-dihydrospiro[2-pyrazoline-5,3′-isoquinolin]-4′(1′H)-one

Akkurt, Mehmet; Yıldırım, Sema Öztürk; Rahima, Badri; Kerbal, Abdelali; Hadda, Taïbi Ben; Büyükgüngör, Orhan

doi:10.1107/s1600536806041018

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…All compounds were characterized using 1 H and 13 C NMR data's which are in agreement with previously reported similar compounds. 13,16,17 The selective NMR data are represented in Tables 1 and 2.…”

Section: Chemistrymentioning

confidence: 99%

Looking for a new antitubercular pharmacophore site: synthesis and bioactivity of spiroheterocycles 2,3',4'-tri-subsituted-1,2-dihydro-4H,4'H-spiro[isoquinoline-3,5'-isoxazol]-4-ones

Hadda¹,

Rahima²,

Kerbal³

et al. 2007

Arkivoc

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Synthesis of a series of fourteen novel 2,3',4'-tri-subsituted-1,2-dihydro-4H,4'Hspiro[isoquinoline-3,5'-isoxazol]-4-ones was accomplished in good yield by regio and stereoselective 1,3-dipolar cycloaddition of p-R 2 -benzadoxime 4-8 with dipolarophiles (3Z)-3-The structure of the isolated products 9-23 was established through different spectroscopic techniques. X-Ray crystal structure analysis of one of the products confirms the structure and the selective region and stereochemistry of this cycloaddition. Their antitubercular activity is also evaluated.

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Section: Chemistrymentioning

confidence: 99%

Looking for a new antitubercular pharmacophore site: synthesis and bioactivity of spiroheterocycles 2,3',4'-tri-subsituted-1,2-dihydro-4H,4'H-spiro[isoquinoline-3,5'-isoxazol]-4-ones

Hadda¹,

Rahima²,

Kerbal³

et al. 2007

Arkivoc

Self Cite

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“…Following the ORTEP of compound 19, 17 it appears that the privileged approach of dipolar reagent 4-8 taken place with inverted regiochemistry to that obtained with chromanone exodipolarophile derivatives. Table 2.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antitubercular activity of spiroheterocycles: 2,2’,4’,5’-tetra-substituted-1,2,2',4'-tetrahydro-4H-spiro[isoquinoline-3,3'-pyrazol]-4-ones

Hadda¹,

Rahima²,

Kerbal³

et al. 2007

Arkivoc

Self Cite

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Synthesis of a series of fourteen novel 2,2',4',5'-tetra-substituted-1,2,2',4'-tetrahydro-4H-spiro[isoquinoline-3,3'-pyrazol]-4-ones was accomplished in good yield by regio and steroselective 1,3-dipolar cycloaddition of α-chloro-aryliden-phenylhydrazones with (3Z)-3-(arylidene)-2-phenyl-2,3-dihydroisoquinolin-4(1H)-ones 4-8 with dipolarophiles [(3Z)-2-phenyl-3-(p-R 1 -phenyl)-2,3-dihydroisoquinolin-4(1H)-ones] 1-3. The structure of the isolated products 9-22 was established through different spectroscopic techniques. X-ray crystal structure analysis of one of the products confirms the structure and the selective region and stereochemistry of this cycloaddition. Their antitubercular activity is evaluated.

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Computational POM evaluation of experimental in vitro Trypanosoma cruzi and Mycobacterium tuberculosis inhibition of heterocyclic-2-carboxylic acid (3-cyano-1,4-di-noxidequinoxalin-2-yl)amide derivatives

Hadda¹,

Bendaha²,

Sheikh³

et al. 2013

Med Chem Res

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4-p-Anisyl-1,2′-diphenyl-3-p-tolyl-2′,3′-dihydrospiro[2-pyrazoline-5,3′-isoquinolin]-4′(1′H)-one

Abstract: Key indicatorsSingle-crystal X-ray study T = 296 K Mean (C-C) = 0.003 Å R factor = 0.042 wR factor = 0.112 Data-to-parameter ratio = 17.8For details of how these key indicators were automatically derived from the article, see

Cited by 3 publications

References 7 publications

Looking for a new antitubercular pharmacophore site: synthesis and bioactivity of spiroheterocycles 2,3',4'-tri-subsituted-1,2-dihydro-4H,4'H-spiro[isoquinoline-3,5'-isoxazol]-4-ones

Looking for a new antitubercular pharmacophore site: synthesis and bioactivity of spiroheterocycles 2,3',4'-tri-subsituted-1,2-dihydro-4H,4'H-spiro[isoquinoline-3,5'-isoxazol]-4-ones

Synthesis and antitubercular activity of spiroheterocycles: 2,2’,4’,5’-tetra-substituted-1,2,2',4'-tetrahydro-4H-spiro[isoquinoline-3,3'-pyrazol]-4-ones

Computational POM evaluation of experimental in vitro Trypanosoma cruzi and Mycobacterium tuberculosis inhibition of heterocyclic-2-carboxylic acid (3-cyano-1,4-di-noxidequinoxalin-2-yl)amide derivatives

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