4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion

Broca, Christophe; Manteghetti, M.; Gross, René; Baissac, Yves; Jacob, Marc C.; Petit, Pierre; Sauvaire, Yves; Ribes, G

doi:10.1016/s0014-2999(00)00030-3

Cited by 143 publications

(101 citation statements)

References 14 publications

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“…As one of the major effects of fenugreek is decreased blood glucose, careful monitoring of glucose levels is needed when it is taken concomitantly with insulin or other glucose-lowering agents. Fenugreek can also exhibit anticoagulant activity; therefore, it should be used under close medical supervision when anticoagulant agents are prescribed [80][81][82][83]. A decrease of serum triglycerides (TGs), total cholesterol, and low-density lipoprotein cholesterol (LDL-C) is observed with fenugreek seed administration.…”

Section: Fenugreek (Trigonella Foenum-graecum L)mentioning

confidence: 99%

“…4-OHIle shows in vitro insulinotropic activity related to the glucose concentration of the medium in isolated pancreatic beta cells [82,83]. Furthermore, this effect has not been observed for sulphonylureas, treatment with which has produced hypoglycaemia as an adverse effect in non-insulin-dependent diabetes mellitus patients.…”

Section: Pharmacological Effects Of 4-hydroxyisoleucine (4-ohile)mentioning

confidence: 99%

“…An improvement in glucose and insulin tolerance, insulin secretion, and reduced hyperglycaemia were observed in diabetic rats and dogs. 4-OHIle functioned as an insulin secretagogue, but only in the presence of elevated blood glucose concentrations, in a range of 8.3-16.7 mM [73,82,83]. …”

Section: Pharmacological Effects Of 4-hydroxyisoleucine (4-ohile)mentioning

confidence: 99%

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4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

Avalos-Soriano

Cruz-Cordero²,

Rosado

et al. 2016

Molecules

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Obesity and insulin resistance (IR) are interdependent multifactorial processes that cannot be understood separately. Obesity leads to systemic inflammation and increased levels of free fatty acids that provoke IR and lipotoxicity. At the same time, IR exacerbates adipose cell dysfunction, resulting in chronic inflammation and major lipotoxic effects on nonadipose tissues. 4-Hydroxyisoleucine (4-OHIle), a peculiar nonprotein amino acid isolated from fenugreek (Trigonella foenum-graecum) seeds, exhibits interesting effects on IR related to obesity. 4-OHIle increases glucose-induced insulin release, and the insulin response mediated by 4-OHIle depends on glucose concentration. The beneficial effects observed are related to the regulation of blood glucose, plasma triglycerides, total cholesterol, free fatty acid levels, and the improvement of liver function. The mechanism of action is related to increased Akt phosphorylation and reduced activation of Jun N-terminal kinase (JNK)1/2, extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), and nuclear factor (NF)-κB. Here, we present a review of the research regarding the insulinotropic and insulin-sensitising activity of 4-OHIle in in vitro and in vivo models.

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Section: Fenugreek (Trigonella Foenum-graecum L)mentioning

confidence: 99%

Section: Pharmacological Effects Of 4-hydroxyisoleucine (4-ohile)mentioning

confidence: 99%

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4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

Avalos-Soriano

Cruz-Cordero²,

Rosado

et al. 2016

Molecules

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“…The increase was attributed to activation of glucokinase hence lowering the glucose threshold for insulin secretion in the pancreas (Rathi et al, 2002). Similarly, T. foenum-graecum extracts increased insulin secretion in animal studies; the increase being attributed to 4-hydroxyleucine, an amino acid mimicking the insulin secreting properties of the gluconeogenic amino acids arginine and leucine (Broca et al, 2000).…”

Section: Increase In Insulin Secretionmentioning

confidence: 98%

Mechanisms of Action of Traditional Herbal Medicines Used in the Management of Diabetes Mellitus: A Review of the Literature

Japhet¹,

Ngcobo²,

Gomo³

2017

Afr J Tradit Complement Altern Med

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Background: The prevalence of diabetes mellitus is increasing rapidly in both developed and developing countries. There are various conventional medicines used for the management of the disease, but there is also increased interest in the use of traditional herbal medicines. Although the concepts of illness and diseases in traditional medicine may differ from conventional medicine the outcomes are similar. The antihyperglycemic effects of various herbal medicines prescribed by traditional healers in the management of diabetes mellitus have been proven scientifically using several in-vitro and in-vivo models as well as clinical studies in humans. Materials and methods: Literature search was done in several databases. Firstly, the search was conducted using the key terms: diabetes mellitus and traditional medicine, diabetes mellitus and herbs, diabetes mellitus and plants, traditional concepts of health and sickness and diabetes mellitus. After identifying the herbs or plants used in diabetes a search was then conducted by name of herb and efficacy in management of diabetes mellitus. Results: This review highlights the similarities and differences in mechanisms of action of various traditional herbal medicines and conventional medicines. The major observation is that, herbal medicines often have multiple mechanisms of action ideally making them combination therapies. The review further highlights the need to develop an algorithm of a minimum battery of in-vitro and animal studies that can provide solid evidence of the potential of traditional medicines as anti-diabetic treatments. Conclusion: Traditional herbal medicines often have multiple phytoconstituents and hence multiple mechanisms of action ideally making them combination therapies.

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“…The absence of cholesterol reduction in this study could be due to the relatively low content of seed in the diet and the lower concentration of steroidal sapogenins in forage compared with seed . The lower concentration of plasma glucose for FEN fed cows compared with ALF may be due to the lower DMI or may be a direct action of fenugreek itself, specifically the presence of 4-hydroxyisoleucine in fenugreek haylage that regulates insulin secretion (Broca et al, 2000).…”

Section: Fenugreek Forage For Dairy Cowsmentioning

confidence: 99%

Fenugreek (Trigonella foenum-graecum L.) as an alternative forage for dairy cows

Alemu

Doepel

2011

Animal

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Fenugreek is a novel forage crop in Canada that is generating interest as an alternative to alfalfa for dairy cows. To evaluate the value of fenugreek haylage relative to alfalfa haylage, six, second lactation Holstein cows (56 6 8 days in milk), which were fitted with rumen cannulas (10 cm i.d., Bar Diamond Inc., Parma, ID, USA) were used in a replicated three 3 three Latin square design with 18-day periods. Diets consisting of 400 g/kg haylage, 100 g/kg barley silage and 500 g/kg concentrate on a dry matter (DM) basis were fed once daily for ad libitum intake. The haylage component constituted the dietary treatments: (i) Agriculture and Agri-Food Canada F70 fenugreek (F70), (ii) Crop Development Center Quatro fenugreek (QUAT) and (iii) alfalfa (ALF). DM intake (DMI), milk yield and milk protein and lactose yields were higher ( P , 0.001) for cows fed ALF than fenugreek (FEN, average of F70 and QUAT). Milk fat of cows fed FEN contained lower concentrations of saturated, medium-chain and hypercholestrolemic fatty acids (FAs; P , 0.05) than that of cows fed ALF. Apparent total tract digestibility of DM and nutrients was not affected by treatments. Similarly, individual ruminal volatile FA concentrations and rumen pH (5.9) were not affected by treatments. Rumen ammonia-N concentration was higher for FEN than ALF ( P , 0.001). Estimates of neutral detergent fiber (NDF) passage rate ( P , 0.05) and NDF turnover rate ( P , 0.001) in the rumen were higher for ALF than FEN. Our results suggest that although the digestibility of the FEN diets was not different from that of the ALF diet, fenugreek haylage has a lower feeding value than ALF for lactating dairy cows due in part to lower DMI and subsequently lower milk yield.

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4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion

Cited by 143 publications

References 14 publications

4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

Mechanisms of Action of Traditional Herbal Medicines Used in the Management of Diabetes Mellitus: A Review of the Literature

Fenugreek (Trigonella foenum-graecum L.) as an alternative forage for dairy cows

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