4‐HPR modulates gene expression in ovarian cells

Brewer, Molly; Kirkpatrick, Nathaniel D.; Wharton, J. Taylor; Wang, Jian; Hatch, Kenneth D.; Auersperg, Nelly; Utzinger, Urs; Gershenson, David M.; Bast, Robert C.; Zou, Changping

doi:10.1002/ijc.21797

Cited by 7 publications

(5 citation statements)

References 63 publications

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“…This study revealed modest responses to 4HPR, suggesting that, although there may be a role for chemoprevention with 4HPR, it likely acts through different pathways in normal, immortalized, and malignant cells. 40 This theory of varying pathways was confirmed and further elucidated by Brewer et al, 41 when they again treated IOSE and OVCA433 cells with 4HPR. DNA microarray was used to evaluate changes in gene expression.…”

Section: In Vitro Datamentioning

confidence: 69%

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The Use of Retinoids in Ovarian Cancer

Whitworth¹,

Straughn²,

Atigadda³

et al. 2012

International Journal of Gynecological Cancer

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Ovarian cancer is the deadliest of all gynecologic malignancies. The search for novel treatment modalities to augment traditional chemotherapy and improve quality of life is ongoing. Retinoids, a class of compounds composed of vitamin A, its natural derivatives, and synthetic analogs, have been studied extensively in both the prevention and treatment of gynecologic malignancies. In this article, we reviewed preclinical studies and clinical trials conducted using retinoids in ovarian cancer.

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Section: In Vitro Datamentioning

confidence: 69%

“…Both lines exhibited down-regulation of mutant BRCA genes. These results indicate that 4HPR may act through different mechanisms to yield a chemopreventive effect in premalignant cells and a chemotherapeutic effect in malignant cells 41. …”

mentioning

confidence: 87%

The Use of Retinoids in Ovarian Cancer

Whitworth¹,

Straughn²,

Atigadda³

et al. 2012

International Journal of Gynecological Cancer

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“…In certain clinical cases, synthetic retinoid derivatives may have advantages over natural ones like ATRA. Fenretinide (R) and CD437 promote apoptosis of ovarian cancer cells [23,24]. Their action is to increase the activity of caspase-3 and caspase-9 enzymes in both ATRA-sensitive (CAOV-3) and resistant (SKOV-3) cells [23,24].…”

Section: Ovarian Cancermentioning

confidence: 99%

“…Fenretinide (R) and CD437 promote apoptosis of ovarian cancer cells [23,24]. Their action is to increase the activity of caspase-3 and caspase-9 enzymes in both ATRA-sensitive (CAOV-3) and resistant (SKOV-3) cells [23,24]. In addition, 4-HPR and CD437 increase the expression of proapoptotic genes and mitochondria uncoupling protein in OVCA433 cells [23,24].…”

Section: Ovarian Cancermentioning

confidence: 99%

“…Their action is to increase the activity of caspase-3 and caspase-9 enzymes in both ATRA-sensitive (CAOV-3) and resistant (SKOV-3) cells [23,24]. In addition, 4-HPR and CD437 increase the expression of proapoptotic genes and mitochondria uncoupling protein in OVCA433 cells [23,24]. It seems interesting that the use of 4-HPR in the preoperative period does not provide significant clinical benefit [25].…”

Section: Ovarian Cancermentioning

confidence: 99%

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Vitamins in Gynecologic Malignancies

Wierzbowska,

Olszowski,

Chlubek

et al. 2024

Nutrients

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The combination of vitamin A and D derivatives with classical chemotherapeutic treatments results in more satisfactory outcomes. The use of drug combinations, such as 9cUAB130 with carboplatin and cisplatin with TAC-101, shows enhanced cytotoxic effects and reductions in ovarian tumor volume compared to single-drug treatments. Combining cisplatin with calcitriol and progesterone increases VDR expression, potentially enhancing the effectiveness of anticancer therapy in ovarian cancer. The effectiveness of vitamin derivatives in anticancer treatment may vary depending on the characteristics of the tumor and the cell line from which it originated. An increase in thiamine intake of one unit is associated with an 18% decrease in HPV infection. Higher intake of vitamin C by 50 mg/day is linked to a lower risk of cervical neoplasia. Beta-carotene, vitamin C, and vitamin E are associated with risk reductions of 12%, 15%, and 9% in endometrial cancer, respectively. A balanced daily intake of vitamins is important, as both deficiency and excess can influence cancer development. It has been observed that there is a U-shaped relationship between group B vitamins and metabolic markers and clinical outcomes.

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Impact of 4HPR on the expression of E-Cad in human bladder transitional epithelial cancer cells T24

Wang

Yang

et al. 2012

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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Previous researches showed that the expression level of E-Cad in most infiltrating cancer cells was reduced or negative. This study explored whether 4HPR restrained the infiltration of bladder cancer cells through regulating the expression of E-Cad. The infiltrating bladder cancer cells T24 were cultured, and then treated by a proper dosage of drug. Their viability was a determined by MTT method. Western blotting and RT-PCR were adopted to detect the changes of E-Cad gene expression at both protein and mRNA levels. Moreover, immunofluorescent staining and confocal fluorescence microscopy were employed for the observation of the expression of E-Cad. The result showed that, at both mRNA and protein levels, the expression level of E-Cad in T24 cells treated by 4HPR was significantly higher than that of control group, while the β-Cat expression was also relocated from the cell nucleus to cytoplasm. Our findings suggested that the regulatory function of 4HPR on infiltration of bladder cancer cells T24 is at least partly achieved by regulating the expression of E-Cad.

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4‐HPR modulates gene expression in ovarian cells

Cited by 7 publications

References 63 publications

The Use of Retinoids in Ovarian Cancer

The Use of Retinoids in Ovarian Cancer

Vitamins in Gynecologic Malignancies

Impact of 4HPR on the expression of E-Cad in human bladder transitional epithelial cancer cells T24

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