4-Hexyl-1,3-phenylenediol, a nuclear factor-κB inhibitor, improves photodamaged skin and clinical signs of ageing in a double-blinded, randomized controlled trial

Kaur, Simarna; Kizoulis, Menas; Fantasia, J.; Oddos, Thierry; Bigot, Nicolas; Galéra, Philippe; Tucker-Samaras, Samantha; Leyden, James J.; Southall, Michael D.

doi:10.1111/bjd.13747

Cited by 10 publications

(13 citation statements)

References 38 publications

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“…NF-κB inhibition can enhance the expression of extracellular matrix (ECM) genes in vitro. In one small eight week randomized clinical trial (RTC), the inhibition of NF-κB was shown to decrease the visible signs of aging [25]. This further corroborates the role of NF-κB in skin aging.…”

Section: Introductionmentioning

confidence: 56%

Anti-aging Effects of Select Botanicals: Scientific Evidence and Current Trends

Campa

Baron

2018

Cosmetics

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As skin ages, there is a decline in physiologic function. These changes are induced by both intrinsic (chronologic) and extrinsic (predominately UV-induced) factors. Botanicals offer potential benefits to combat some of the signs of aging. Here, we review select botanicals and the scientific evidence behind their anti-aging claims. Botanicals may offer anti-inflammatory, antioxidant, moisturizing, UV-protective, and other effects. A multitude of botanicals are listed as ingredients in popular cosmetics and cosmeceuticals, but only a select few are discussed here. These were chosen based on the availability of scientific data, personal interest of the authors, and perceived “popularity” of current cosmetic and cosmeceutical products. The botanicals reviewed here include argan oil, coconut oil, crocin, feverfew, green tea, marigold, pomegranate, and soy.

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Section: Introductionmentioning

confidence: 56%

Anti-aging Effects of Select Botanicals: Scientific Evidence and Current Trends

Campa

Baron

2018

Cosmetics

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“…Hence, the blackberrydill combination identified here could potentially be used for wrinkle-reducing treatment to provide anti-ageing skin benefits. Although other studies have shown elastogenesis stimulation through single ingredients [11,18,[43][44][45], this is the first study to use a comprehensive approach to upregulate elastogenesis stimulation in adults by combining two extracts that increase skin's functional elastic fibre production as well as prevent their degradation. Taken together, our studies identified a combination of two complementary natural extracts with elastogenic, skinfirming and sagging-reducing benefits for ageing and photodamaged skin.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to UV exposure, other factors can also impact elastin in skin. Induction of the inflammatory mediator, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-jB), has been shown to repress elastin and collagen gene expression and to contribute to the clinical appearance of photodamaged skin [11]. Taken together, elastin expression and organization can be negatively affected in skin resulting in the loss of elasticity seen in ageing and photodamaged skin.…”

Section: Introductionmentioning

confidence: 99%

A blackberry–dill extract combination synergistically increases skin elasticity

Meza

Seo

et al. 2020

Intern J of Cosmetic Sci

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Background The loss of structural elastin due to intrinsic and extrinsic ageing results in the skin’s inability to stretch and recoil (decrease in elasticity) and manifests as loss of skin firmness and sagging. While other extracellular matrix (ECM) components such as collagen and hyaluronic acid are continually synthesized and assembled through life, elastic fibres are not. Elastic fibre assembly and functionality require fibre cross‐linking, induced by the lysyl oxidase‐like (LOXL) enzymes, which sharply decrease during ageing. Objective To evaluate the enhanced elastogenic effect of a blackberry–dill extract combination, which was hypothesized to induce elastin fibre component synthesis, fibre cross‐linking and reduce elastin fibre degradation. Methods The blackberry and the dill extracts were tested separately and in combination to confirm single ingredient bioactivity and synergistic benefits. Human skin explants, dermal fibroblasts, elastase assays, ELISAs, quantitative real‐time PCRs and spectrofluorometer measurements were used. Moreover, a double‐blinded, placebo‐controlled clinical study was carried out to assess skin elasticity using Cutometer and histologically from biopsies. Results The blackberry extract induced elastin gene expression, elastin promoter activity and inhibited elastic fibre degradation by matrix metalloproteinases (MMPs) 9 and 12. The dill extract induced elastin, collagen and LOXL1 gene expression, resulting in enhanced fibre cross‐linking in human skin explants. Clinically, the blackberry and dill combination treatment displayed synergistic pro‐elasticity activity as compared to each ingredient alone and placebo. Conclusion Taken together, these results demonstrated the two multimodal plant‐based extracts complemented each other in terms of bioactivity and resulted in a synergistic elastogenesis induction.

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“…Evidence that this is indeed the case has been presented in a clinical study that tested the effect of topically administered 4-hexyl-1,3-phenylenediol, an NF-kB inhibitor on photo-damaged skin. After eight weeks of use, patients being treated with the NF-kB inhibitor showed significant improvement in crow's feet fine lines, cheek wrinkles, age spots, mottled pigmentation and radiance [218]. A role for NF-kB in contributing to chronological aging has been demonstrated in studies with fibroblasts obtained from donors over the age of 50.…”

mentioning

confidence: 99%

“…These cells showed increased basal NF-kB activity, consistent with a slow increase in inflammation that occurs in aging skin. Treatment of these fibroblasts with 4-hexyl-1,3-phenylenediol, increased the expression of extracellular matrix (ECM) genes [218].…”

mentioning

confidence: 99%

Role of PGE-2 and Other Inflammatory Mediators in Skin Aging and Their Inhibition by Topical Natural Anti-Inflammatories

Fuller

2019

Cosmetics

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Human skin aging is due to two types of aging processes, “intrinsic” (chronological) aging and “extrinsic” (external factor mediated) aging. While inflammatory events, triggered mainly by sun exposure, but also by pollutants, smoking and stress, are the principle cause of rapid extrinsic aging, inflammation also plays a key role in intrinsic aging. Inflammatory events in the skin lead to a reduction in collagen gene activity but an increase in activity of the genes for matrix metalloproteinases. Inflammation also alters proliferation rates of cells in all skin layers, causes thinning of the epidermis, a flattening of the dermo-epidermal junction, an increase in irregular pigment production, and, finally, an increased incidence of skin cancer. While a large number of inflammatory mediators, including IL-1, TNF-alpha and PGE-2, are responsible for many of these damaging effects, this review will focus primarily on the role of PGE-2 in aging. Levels of this hormone-like mediator increase quickly when skin is exposed to ultraviolet radiation (UVR), causing changes in genes needed for normal skin structure and function. Further, PGE-2 levels in the skin gradually increase with age, regardless of whether or not the skin is protected from UVR, and this smoldering inflammation causes continuous damage to the dermal matrix. Finally, and perhaps most importantly, PGE-2 is strongly linked to skin cancer. This review will focus on: (1) the role of inflammation, and particularly the role of PGE-2, in accelerating skin aging, and (2) current research on natural compounds that inhibit PGE-2 production and how these can be developed into topical products to retard or even reverse the aging process, and to prevent skin cancer.

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4-Hexyl-1,3-phenylenediol, a nuclear factor-κB inhibitor, improves photodamaged skin and clinical signs of ageing in a double-blinded, randomized controlled trial

Abstract: Inhibition of the proinflammatory NF-κB pathway resulted in increased expression of ECM proteins in vitro and significant clinical improvement in photodamaged skin.

Cited by 10 publications

References 38 publications

Anti-aging Effects of Select Botanicals: Scientific Evidence and Current Trends

Anti-aging Effects of Select Botanicals: Scientific Evidence and Current Trends

A blackberry–dill extract combination synergistically increases skin elasticity

Role of PGE-2 and Other Inflammatory Mediators in Skin Aging and Their Inhibition by Topical Natural Anti-Inflammatories

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