4′-Fluorouridine inhibits alphavirus replication and infection
in vitro
and
in vivo
Peiqi Yin,
Nicholas A. May,
Laura Sandra Lello
et al.
Abstract:Chikungunya virus (CHIKV) is an enveloped, positive-sense RNA virus that has re-emerged to cause millions of human infections worldwide. In humans, acute CHIKV infection causes fever and severe muscle and joint pain. Chronic and debilitating arthritis and joint pain can persist for months to years. To date, there are no approved antivirals against CHIKV. Recently, the ribonucleoside analog 4′-fluorouridine (4′-FlU) was reported as a highly potent orally available inhibitor of SARS-CoV-2, respiratory syncytial … Show more
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