4‐Ethylpyridine

Abstract

4‐Ethylpyridine product: 4‐ethylpyridine product: 4‐propylpyridine product: 4‐ n ‐butylpyridine product: 4‐isobutylpyridine product: 4‐isoamylpyridine product: 4‐ n ‐octylpyridine

Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV-1 infection

“…10 1-(2-naphthyl)-2-thiourea was prepared from 2-naphthylamine as previously published. 13,14 S-methyl-N-(1- or 2-)-naphthylisothiouronium iodide was prepared as previously published 10 by the addition of methyl iodide to the thioureas. Addition of the naphthylguanide reagent (S-methyl-naphthylisothiouronium iodide, in excess) to the amine compounds, spermine and spermidine, was performed in 1:1 acetonitrile:water at reflux for approximately 24 h. The pH of the reactions were monitored and adjusted with 1 M NaOH when it fell below pH~8.…”