4-Ethoxymethylphenol: a novel phytoestrogen that acts as an agonist for human estrogen receptors

Pearce, Virginia; Nawaz, Zafar; Xiao, Wei; Wiedenfeld, David; Boyle, Nick; Smith, Don W.

doi:10.1016/s0960-0760(03)00064-5

Cited by 10 publications

(7 citation statements)

References 38 publications

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“…For example, a component of ginseng saponin (a ginsenoside), a 4-ethoxymethylphenol, some catechins, and the phytochemical lindleyin may act as agonists/antagonists of estrogens via the ER␣ and ER␤ pathway, depending on their concentration and tissue type [30][31][32][33][34]. In addition, recent studies in our laboratory revealed that plant-derived arylobenzofurans exhibit SERM-like properties [35,36].…”

Section: Discussionmentioning

confidence: 99%

“…The estrogen agonist/antagonist activities of phytoestrogens may be intervened differently by certain tissue-specific ER modifiers, such as cofactors, coactivators and corepressors [14,37]. Indeed, previous reports have shown that plant compounds, such as genistein and 4EM, like estradiol, are influenced by certain ER modifiers (cofactors, coactivators and corepressors) [31,38].…”

Section: Discussionmentioning

confidence: 99%

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Acteoside and martynoside exhibit estrogenic/antiestrogenic properties

Papoutsi

Kassi

Mitakou

et al. 2006

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acteoside and martynoside exhibit estrogenic/antiestrogenic properties

Papoutsi

Kassi

Mitakou

et al. 2006

The Journal of Steroid Biochemistry and Molecular Biology

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“…Phytoestrogens are a group of non‐steroidal polyphenols found in a variety of plants and dietary products, particularly soy and soy‐based foods and supplements (Xu et al ., ). These compounds exert weak estrogenic activity as partial agonists of the estradiol receptor (Lee et al ., ; Mueller et al ., ; Pearce et al ., ; Rickard et al ., ). Their potential reproductive effects were initially described in sheep.…”

Section: Introductionmentioning

confidence: 99%

Male soy food intake was not associated with in vitro fertilization outcomes among couples attending a fertility center

et al. 2015

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Male factor etiology may be a contributing factor in up to 60% of infertility cases. Dietary intake of phytoestrogens has been related to abnormal semen quality and hormone levels. However, its effect on couple fecundity is still unclear. Intake of soy products was assessed in 184 men from couples undergoing infertility treatment with in vitro fertilization (IVF). Couples were recruited between February 2007 and May 2014 and prospectively followed to document treatment outcomes including fertilization, implantation, clinical pregnancy and live birth. Multivariate generalized linear mixed models with random intercepts, binomial distribution and logit link function were used to examine this relation while accounting for repeated treatment cycles and adjusting for potential confounders. Male partner’s intake of soy foods and soy isoflavones was unrelated to fertilization rates, the proportions of poor quality embryos, accelerated or slow embryo cleavage rate, and implantation, clinical pregnancy and live birth. The adjusted live birth rates per initiated cycle (95% CI) for partners of men in increasing categories of soy food intake were 0.36 (0.28 to 0.45), 0.42 (0.29 to 0.56), 0.36 (0.24 to 0.51), and 0.37 (0.24 to 0.52), respectively. Soy food intake in men was not related to clinical outcomes among couples presenting at an infertility clinic. Data on the relation between phytoestrogens and male reproductive potential remains scarce and additional research is needed to clarify its role in human reproduction.

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“…(1) Phytoestrogens are peripheral partial agonists of estradiol receptors (ER) with, varying affinity for each receptor subtype but generally exert weak estrogenic activity (2–5). These compounds first gained prominence in the reproductive literature in the late 1940’s, when remarkable breeding problems in sheep subsequently known as Clover disease were linked to feeding on newly introduced clover pastures rich in phytoestrogens (6–8).…”

Section: Introductionmentioning

confidence: 99%

Soy food intake and treatment outcomes of women undergoing assisted reproductive technology

Vanegas

Afeiche²,

Gaskins

et al. 2015

Fertility and Sterility

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Objective To study the relation of dietary phytoestrogens intake and clinical outcomes of women undergoing infertility treatment with assisted reproductive technology (ART). Design Prospective cohort study. Setting Fertility center in an academic hospital. Participants 315 women who collectively underwent 520 ART cycles between 2007 and 2013. Interventions None Outcomes Primary outcomes were implantation, clinical pregnancy and live birth rates per initiated cycle. Results Soy isoflavones intake was positively related to live birth rates in ART. Compared to women who did not consume soy isoflavones, the multivariable-adjusted odds ratios of live birth (95% confidence interval) for women in increasing categories of soy isoflavone intake were 1.32 (0.76–2.27) for women consuming 0.54–2.63 mg/d, 1.87 (1.12–3.14) for women consuming 2.64- 7.55 mg/d, and 1.77 (1.03–3.03) for women consuming 7.56- 27.89 mg/d. Conclusions Dietary soy intake was positively related to the probability of having a live birth during infertility treatment with ART.

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4-Ethoxymethylphenol: a novel phytoestrogen that acts as an agonist for human estrogen receptors

Cited by 10 publications

References 38 publications

Acteoside and martynoside exhibit estrogenic/antiestrogenic properties

Acteoside and martynoside exhibit estrogenic/antiestrogenic properties

Male soy food intake was not associated with in vitro fertilization outcomes among couples attending a fertility center

Soy food intake and treatment outcomes of women undergoing assisted reproductive technology

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