4. Coeliac disease

Barr, Gavin; Grehan, Martin

doi:10.5694/j.1326-5377.1998.tb140201.x

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…The diagnosis is based on serological analysis of speci c autoantibodies against gliadin and endomysium in combination with intestinal biopsy. The disorder is life-long and is associated with an increased risk for malignant lymphoma (1,2).…”

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confidence: 99%

Coeliac disease is associated with intrauterine growth and neonatal infections

Sandberg-Bennich¹,

Dahlquist²,

Källén³

2002

Acta Paediatrica

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confidence: 99%

Coeliac disease is associated with intrauterine growth and neonatal infections

Sandberg-Bennich¹,

Dahlquist²,

Källén³

2002

Acta Paediatrica

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“…The disorder is life-long and is associated with an increased risk for malignant lymphoma (1,2). Through a process not yet fully understood, the prolamines induce an in ammatory reaction in the small intestines which can give a wide range of symptoms; these range from asymptomatic disease to pronounced gastrointestinal symptoms and malnutrition.…”

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confidence: 99%

Coeliac disease is associated with intrauterine growth and neonatal infections

2002

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Sandberg-Bennich S, Dahlquist G, Källén B. Coeliac disease is associated with intrauterine growth and neonatal infections. Acta Paediatr 2002; 91: 30-33. Stockholm. ISSN 0803-5253 To investigate whether factors in the fetal or neonatal period in uence the risk of later development of coeliac disease we conducted a population-based register study. The Swedish Medical Birth Register was linked with the Hospital Discharge Register and identi ed 3392 singleton infants born in the period 1987-97 who developed coeliac disease. Perinatal data for these children were compared with all children born in these years. Exposure variables: Maternal age, parity and smoking habits in early pregnancy, preeclampsia, pregnancy duration and birthweight, birthweight by gestational week, Apgar score, neonatal icterus, neonatal infections, maternal-fetal blood group incompatibility, exchange transfusion, phototherapy. Odds ratios and test-based con dence intervals were calculated. Analyses were made with strati cation for year of birth and other risk factors. The risk of developing coeliac disease decreased with maternal age and was lower in rst-born than in second-born children. Maternal smoking in early pregnancy was a weak risk factor, as was low birthweight. The most evident risk factors were being exposed to neonatal infections (OR = 1.52, con dence limits 1.19; 1.95) and being small for gestational age (OR = 1.45, con dence limits 1.20; 1.75). These risk factors were independent of each other. Conclusions:We have demonstrated that the intrauterine environment, mainly as mirrored by a low birthweight for gestational age and, independently, neonatal infection diagnosis, is associated with the risk of developing coeliac disease, supporting the idea of a multifactorial aetiology of the disease.

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“…1 Isolated iron and/or folate deficiency anaemia are also common forms of presentation. 2 The clinical features have also changed in children. Coeliac disease should be suspected in children with growth or pubertal failure, recurrent abdominal pain, iron and/or folate deficiency or malaise.…”

Section: Clinical Featuresmentioning

confidence: 99%

Diagnostic Tests: Gluten enteropathy

Selby¹

2001

Aust Prescr

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The presentation of coeliac disease is changing, and typical malabsorption is now uncommon. Patients are more likely to present with non-specific symptoms or with iron and/or folate deficiency. The diagnosis still depends upon finding villous atrophy in the small intestine by endoscopic biopsy of the distal duodenum. The mucosal changes should improve after the patient has followed a gluten-free diet for at least six months.IgA antibodies to gliadin, endomysium and/or tissue transglutaminase are detectable in most untreated patients. Antibody testing should not be used alone to make the diagnosis, because of the possibility of false positive results. This testing is used in patients where the clinical index of suspicion is low, in those with one of the disorders associated with coeliac disease or for screening relatives. Everyone with detectable antibodies requires a small bowel biopsy. Patients in whom the clinical index of suspicion of the disease is high should undergo biopsy regardless of the results of antibody testing. There is no place for an empirical trial of a gluten-free diet if coeliac disease is suspected.

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4. Coeliac disease

Cited by 7 publications

References 18 publications

Coeliac disease is associated with intrauterine growth and neonatal infections

Coeliac disease is associated with intrauterine growth and neonatal infections

Coeliac disease is associated with intrauterine growth and neonatal infections

Diagnostic Tests: Gluten enteropathy

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