4-Chloro-3-(trifluoroacetyl)coumarin as a novel building block for the synthesis of 7-(trifluoromethyl)-6H-chromeno[4,3-b]quinolin-6-ones

Thermolysis of N‐Aryl Enaminoimine Hydrochloride Derivatives: A Short and General Method for the Synthesis of Pyranoquinolin‐3‐one and Pyranoacridin‐3‐one Derivatives

“…Chromenoquinoline derivatives have been reported to act as human progesterone receptor and have been used therapeutically. Although coming across the literature, we found a gradual increase on the studies towards the synthesis of pyridocoumarin derivatives since 1999 and in the last decade, a large number of synthesis of such compounds have been reported by various groups especially by Majumdar et al . .…”

A Concise Review on Pyridocoumarin/Azacoumarin Derivatives: Synthesis and Biological Activity

“…Iaroshenko and his group reported to have synthesised a series of tetracyclic pyridocoumarins [7‐(trifluoromethyl)‐6 H‐ chromeno[4,3‐ b ]quinolin‐6‐one derivatives 92 ] in good to excellent yield beginning with available anilines (as D‐ring precursors) and 4‐chloro‐3‐(trifluoroacetyl)coumarin 89 (as AB ring precursor) which was prepared from 4‐hydroxy coumarin (Scheme ).…”

Synthesis and Biological Evaluation of Novel Thiazolyl-Coumarin Derivatives as Potent Histone Deacetylase Inhibitors with Antifibrotic Activity

“…These compounds belong to the lactone family and are composed of benzene rings condensed onto an α–pyrone ring. In recent years the use of the coumarin ring as a scaffold molecule has occupied an important place in the investigation of new drugs possessing different pharmacological activities such as antibacterial, antiviral, anticancer, anticoagulant, anti-inflammatory, antioxidant and analgesic effects [21,22]. Moreover, coumarin–based benzamides and osthole have been used successfully as CAP in new iHDACs synthesis [23,24].…”