4-Chloro-3-formylcoumarin as a multifaceted building block for the development of various bio-active substituted and fused coumarin heterocycles: a brief review

Abstract

This paper reviews the research data in the literature on the chemistry of 4-chloro-3-formylcoumarins reported over the period of 2-3 dacades. It covers the synthetic applicability of 4-chloro-3-formylcoumarins for the...

Base-promoted synthesis of dihydrochromeno[4,3-d]pyrrolo[3,4-b]pyridines from 4-chloro-3-substituted coumarins and α-aminomaleimides

“…Recently, 4-chloro-3-substituted coumarins have been attracting the attention of organic chemists as the most reactive elec-trophiles and the most readily available starting materials for the synthesis of heterocyclic systems based on coumarins. 24 Our group has shown great interest in investigating multicomponent reactions using this targeted heterocycle. Using it, we produced new complex molecular scaffolds containing the coumarin skeleton.…”

An Overview on the Synthesis of Fused Pyridocoumarins with Biological Interest

“…The 4-chloro-3-formylcoumarins 251 , used in the above reactions, are very versatile tools for the synthesis of fused pyridocoumarins [ 67 ]. In 1995, Heber et al, synthesized 3-substituted [1]benzopyrano [4,3-b]pyridine-5-ones 28j – l from the treatment of 4-alkylamino-3-alkenylcoumarins 268a – k under Vilsmeier conditions [ 166 ].…”

“…(Rubiaceae), a tree found in west central Africa, and possess anti-HIV activity [ 60 , 61 , 62 , 63 ]. Even though several reviews referring the chemistry and biological aspects of coumarins and fused coumarins have been published to date, there are few reviews containing topics on the chemistry and biological activity of fused pyridocoumarins [ 11 , 42 , 64 , 65 , 66 , 67 ]. In this review, we present an overview of the advances described in the literature on the synthesis and biological evaluation of fused pyridocoumarins.…”

Mini Review on Pyrido[2,3-c]coumarins Backbone of Santiagonamine Antibiotics

“…It was extracted from stems and branches of the South American shrub Berberis darwinii Hook. A large number of synthetic pyridocoumarins [21][22][23][24][25][26][27][28][29][30][31][32][33][34] are known to exhibit diverse biological facets, including anti-bacterial, anti-microbial, anti-malarial, antipsychotic (dopamine D4 receptor antagonists) anti-fungal, anti-cancer, [35][36][37][38][39][40][41][42][43] and anti-Huntington's 44 and anti-ecto-5′-nucleotidase (e5′NT) enzymatic 45 activity. In addition, these compounds act as bronchodilator agents, 46 and are used as excellent fluorescence probes.…”