4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors
Maksym Platonov,
Oleksandr Maximyuk,
Alexey Rayevsky
et al.
Abstract:Acid-sensing ion channels (ASICs) play a key role in the perception and response to extracellular acidification changes. These proton-gated cation channels are critical for neuronal functions, like learning and memory, fear, mechanosensation and internal adjustments like synaptic plasticity. Moreover, they play a key role in neuronal degeneration, ischemic neuronal injury, seizure termination, pain-sensing, etc. Functional ASICs are homo or heterotrimers formed with (ASIC1–ASIC3) homologous subunits. ASIC1a, a… Show more
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