4‐Aryl‐1H‐isochromenes Synthesis from Triol Derivatives through Brønsted Acid‐Catalyzed Pinacol Rearrangement/Intramolecular Cyclization Sequence
Winai Ieawsuwan,
Suphaporn Limjirawatthana,
Poonsakdi Ploypradith
et al.
Abstract:4‐Aryl‐1H‐isochromene derivatives have been successfully synthesized by Brønsted acid‐catalyzed pinacol rearrangement/intramolecular cyclization of the substituted 1‐(2‐(hydroxymethyl)phenyl)‐2‐arylethane‐1,2‐diols. The reaction generally proceeded with low catalyst loading of trifluoromethanesulfonic acid (5 mol%) for short reaction times (10‐20 min) to furnish the desired 4‐aryl‐1H‐isochromenes which were subsequently hydrogenated to 4‐aryl‐isochromans with up to 90% yield. Moreover, oxidation of the resulti… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.