Transgender youth are those whose genders do not align with their sex assigned at birth. Transgender youth are increasingly visible and frequently encounter discrimination and a lack of understanding from others, especially at school. As a result, they experience profound mental health challenges, with transgender youth being 6 times more likely to attempt suicide compared to cisgender youth. However, transgender youth who are adequately supported do not experience serious mental health difficulties. Accordingly, promoting school support for transgender youth is critical. While school staff know how to help youth generally, many want more guidance on how to help transgender youth. This article provides best practices for school staff to help transgender youth.