4-Aminosalicylic Acid Enemas for Ulcerative Colitis

Sharma, Manish; Duphare, H. V.

doi:10.1016/s0140-6736(89)90056-1

Cited by 2 publications

(1 citation statement)

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“… 2 The isomeric drug, 4‐aminosalicylic acid (4‐ASA), has been employed since the 1940s as a treatment for tuberculosis. More recently, however, various authors have shown that rectal administration of 4‐ASA is an effective alternative to 5‐ASA in the treatment of ulcerative colitis 2–9 . The rectal route, however, is not convenient or acceptable for most patients, and therefore such patients would benefit from an oral alternative to chronic enema therapy.…”

Section: Introductionmentioning

confidence: 99%

Colonic delivery of 4‐aminosalicylic acid using amylose–ethylcellulose‐coated hydroxypropylmethylcellulose capsules

Tuleu

Basit

Waddington

et al. 2002

Aliment Pharmacol Ther

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SUMMARYBackground: 4-Aminosalicylic acid has the potential for use in the treatment of diseases of the colon. Aim: To assess the feasibility of delivering 4-aminosalicylic acid directly to the colon using a hydroxypropylmethylcellulose capsule coated with a mixture of amylose, a polysaccharide metabolized by bacterial enzymes in the colon, and ethylcellulose. Methods: Seven healthy male volunteers received, on three separate occasions, an uncoated or amyloseethylcellulose-coated hydroxypropylmethylcellulose capsule containing 4-aminosalicylic acid Na (550 mg), or an intravenous injection of 4-aminosalicylic acid Na (135 mg). The capsules were radiolabelled with 99m Tc

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Section: Introductionmentioning

confidence: 99%