Abstract:The effects induced by nitric oxide (NO) in different tissues depend on direct and/or indirect interactions with K + channels. The indirect interaction of NO is produced by activation of guanylyl cyclase which increases the intracellular cGMP. Since NO, cGMP and 4-aminopyridine alone induce tetanic fade and increase amplitude of muscular contractions in isolated rat neuromuscular preparations, the present study was undertaken to determine whether or not the neuromuscular effects of NO and 8-Br-cGMP can be modi… Show more
“…Using the substrate of NOS L-arginine and the inhibitors of NOS-L-NMMA and L-NOARG it was shown on rat diaphragm muscle that NO increased the amplitude of muscle contraction by acting on the presynaptic level but decreased them by acting on the postsynaptic level (Ambiel and Alves-Do-Prado 1997;Silva et al 1999;Queiroz et al 2003). Using the substrate of NOS L-arginine and the inhibitors of NOS-L-NMMA and L-NOARG it was shown on rat diaphragm muscle that NO increased the amplitude of muscle contraction by acting on the presynaptic level but decreased them by acting on the postsynaptic level (Ambiel and Alves-Do-Prado 1997;Silva et al 1999;Queiroz et al 2003).…”
“…Using the substrate of NOS L-arginine and the inhibitors of NOS-L-NMMA and L-NOARG it was shown on rat diaphragm muscle that NO increased the amplitude of muscle contraction by acting on the presynaptic level but decreased them by acting on the postsynaptic level (Ambiel and Alves-Do-Prado 1997;Silva et al 1999;Queiroz et al 2003). Using the substrate of NOS L-arginine and the inhibitors of NOS-L-NMMA and L-NOARG it was shown on rat diaphragm muscle that NO increased the amplitude of muscle contraction by acting on the presynaptic level but decreased them by acting on the postsynaptic level (Ambiel and Alves-Do-Prado 1997;Silva et al 1999;Queiroz et al 2003).…”
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