4-Aminopyrazolopyrimidine scaffold and its deformation in the design of tyrosine and serine/threonine kinase inhibitors in medicinal chemistry

Abstract

4-aminopyrazolopyrimidine scaffold has been an interesting pharmacophore since the disclosed of the intimate connection of small-molecule inhibitors and treatment of diseases. Modification of 4-aminopyrazolopyrimidine scaffold according to different target, especially...