4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype

Chang, Tsu‐Chung; Yeh, Chi‐Tai; Bamodu, Oluwaseun Adebayo; Lin, Ying‐Chin; Deng, Li; Rao, Yerra Koteswara; Huang, Chun Chih; Lee, Wei Hwa; Wu, Alexander T.H.; Hsiao, Michael; Wu, Chih Hsiung; Wang, Liang Shun; Tzeng, Yew Min

doi:10.1016/j.taap.2015.07.025

Cited by 43 publications

(32 citation statements)

References 39 publications

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“…Based on this observation, the expression of specific cell surface or cytoplasmic biomarkers of CSCs was further investigated. Since widely accepted biomarkers of colon CSCs have not yet been defined, four potential and frequently-used biomarkers, including CD44, CD133, CD24 and EpCAM (also known as ESA) were chosen to identify colon CSCs (27)(28)(29)(30). As a transmembrane glycoprotein, CD44 possesses a particular cell adhesion function, and consequently assists the matrix adhesion and migration of CSCs (31).…”

Section: Discussionmentioning

confidence: 99%

Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells

Yang

Wang

et al. 2018

Int J Oncol

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Resistance to conventional chemotherapeutic agents, including irinotecan (CPT‑11), 5-fluorouracil and capecitabine is a major cause for therapeutic failure in patients with colorectal cancer (CRC). Increasing evidence has demonstrated that cancer cells exhibiting stem cell-like characteristics are associated with the development of resistance to chemotherapeutic agents. As a plant polyphenol, curcumin has been demonstrated to have the ability to ameliorate resistance of CRC to chemotherapeutic agents, but the associations among curcumin, cancer stem cells (CSCs) and chemoresistance of CRC remain unclear. The present study established a CPT‑11-resistant colon cancer cell line, LoVo/CPT‑11 cells, and detected the expression levels of CSC identification markers [cluster of differentiation (CD)44, CD133, epithelial cell adhesion molecule (EpCAM) and CD24] in parental cells and CPT‑11-resistant cells. It was revealed that the expression levels of the colon CSC markers in LoVo/CPT‑11 cells were significantly higher compared those in parental cells at the mRNA and protein level. The effect of curcumin on the chemoresistance to CPT‑11 and the expression levels of CSC identification markers in LoVo/CPT‑11 cells separately treated with curcumin and CPT‑11 were further investigated. The results revealed that curcumin significantly attenuated chemoresistance to CPT‑11, and treatment with curcumin resulted in a significant reduction of the expression levels of CSC identification markers. Furthermore, a tumor sphere formation assay was used to enrich colon CSCs from LoVo/CPT‑11 cells, and demonstrated that curcumin efficiently diminished the traits of colon CSCs, as evidenced by the inability to form tumor spheres, the reduction in the expression of CSC identification markers, and apoptosis-induced effects on sphere-forming cells treated with curcumin alone or in combination with CPT‑11. Altogether, the present data demonstrated that curcumin attenuated resistance to chemotherapeutic drugs through induction of apoptosis of CSCs among colon cancer cells. These findings may provide novel evidence for the therapeutic application of curcumin in CRC intervention.

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Section: Discussionmentioning

confidence: 99%

Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells

Yang

Wang

et al. 2018

Int J Oncol

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“…On the other hand, in the field of hematologic malignancies, in which CSCs have been well studied, the population of CSCs has been reported to be <1% (35,37). Furthermore, some studies suggested that CSCs were enriched using two surface epitopes, such as CD44 and CD166 or CD44 and CD133 (7,(38)(39)(40). We have analyzed the expression of CD44 and CD133, but there was considerable variation in population of CD44 and CD133 between cell lines (HCT116; 35.5 AE 3.3%, SW480; 0.1 AE 0%, DLD1; 0.1 AE 0%) similar to previous reports (7,(38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, some studies suggested that CSCs were enriched using two surface epitopes, such as CD44 and CD166 or CD44 and CD133 (7,(38)(39)(40). We have analyzed the expression of CD44 and CD133, but there was considerable variation in population of CD44 and CD133 between cell lines (HCT116; 35.5 AE 3.3%, SW480; 0.1 AE 0%, DLD1; 0.1 AE 0%) similar to previous reports (7,(38)(39)(40). This discrepancy in the colorectal cancer population indicates that cell-surface markers cannot be accurately used to purify true CSCs but result in enrichment of the CSC population.…”

Section: Discussionmentioning

confidence: 99%

Cancer Stem-like Properties in Colorectal Cancer Cells with Low Proteasome Activity

Munakata

Uemura

Tanaka

et al. 2016

Clinical Cancer Research

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“…According to the findings, ergosterol peroxide inhibited the nuclear β-catenin level, which resulted in the down-regulation of downstream genes. In another recent study, 43 investigators claimed much better effect of 4-acetylantroquinonol (4-AAQB), closely related to a well-known antroquinonol, in suppressing colorectal cancer and cancer stem-like phenotype. As per their findings, 4-AAQB negatively regulates the genes responsible for the oncogenic effect and the signal transduction pathways that are involved in stemness.…”

Section: Wnt/β-catenin Pathway As a Therapeutic Target In Cancermentioning

confidence: 99%

A Preclinical Evaluation of the Antitumor Activities of Edible and Medicinal Mushrooms: A Molecular Insight

et al. 2017

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Cancer is the leading cause of morbidity and mortality around the globe. For certain types of cancer, chemotherapy drugs have been extensively used for treatment. However, severe side effects and the development of resistance are the drawbacks of these agents. Therefore, development of new agents with no or minimal side effects is of utmost importance. In this regard, natural compounds are well recognized as drugs in several human ailments, including cancer. One class of fungi, “mushrooms,” contains numerous compounds that exhibit interesting biological activities, including antitumor activity. Many researchers, including our own group, are focusing on the anticancer potential of different mushrooms and the underlying molecular mechanism behind their action. The aim of this review is to discuss PI3K/AKT, Wnt-CTNNB1, and NF-κB signaling pathways, the occurrence of genetic alterations in them, the association of these aberrations with different human cancers and how different nodes of these pathways are targeted by various substances of mushroom origin. We have given evidence to propose the therapeutic attributes and possible mode of molecular actions of various mushroom-originated compounds. However, anticancer effects were typically demonstrated in in vitro and in vivo models and very limited number of studies have been conducted in the human population. It is our belief that this review will help the research community in designing concrete preclinical and clinical studies to test the anticancer potential of mushroom-originated compounds on different cancers harboring particular genetic alteration(s).

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4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype

Cited by 43 publications

References 39 publications

Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells

Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells

Cancer Stem-like Properties in Colorectal Cancer Cells with Low Proteasome Activity

A Preclinical Evaluation of the Antitumor Activities of Edible and Medicinal Mushrooms: A Molecular Insight

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