4-[5-(2-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzohydrazide

Abstract

4-(5-(2-Methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzohydrazide (5) was synthesized by three steps. The synthesis started with 2-methoxybenzohydrazide to form hydrazone (3) which was then cyclized to oxadiazole (4) and finally, treatment of oxadiazole (4) with hydrazine hydrate afforded the final product (5).

Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase

“…In a continued effort in search for biologically active molecules [20][21][22][23][24][25][26][27], here we are reporting synthesis of thiazole derivatives and their α-glucosidase inhibition activity not published earlier.…”

Synthesis of Novel Bisindolylmethane Schiff bases and Their Antibacterial Activity

“…As a continuation of our work on bioactive compounds [38,39,40,41,42,43]. Bisindolylmethane Schiff bases 3 – 26 were evaluated for their ability to inhibit both Gram-positive and Gram-negative bacterial strains using the disc diffusion method [44].…”

Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors

“…Our research group has been involved for a decade in lead discovery programs in search of novel therapeutic agents. We have earlier reported Schiff bases of different classes of organic compounds in the search for lead molecules with different biological activities [32][33][34]. Earlier, our group reported the leishmanicidal and β-glucurinodase inhibition potential of hydrazides derived from the corresponding esters [35][36][37][38].…”