4-[(4-Methoxybenzenesulfonamido)methyl]cyclohexane-1-carboxylic acid

Abstract

In the title compound, C15H21NO5S, two crystallographically independent mol­ecules are linked into a dimer by a pair of N—H⋯O hydrogen bonds, forming an R 2 2(8) ring motif. In the crystal, mol­ecules are further linked by inter­molecular O—H⋯O hydrogen bonds into a two-dimensional network parallel to (012). Additional stabilization is provided by weak inter­molecular C—H⋯O hydrogen bonds.

Synthesis and description of intermolecular interactions in new sulfonamide derivatives of tranexamic acid

“…The bond lengths and bond angles observed in (VIII-XI) have normal values, and are comparable to related structures[25][26]. The plane produced from the atoms of cyclohexane ring in molecule VIII shows relative mean square (r.m.s.)…”

“…The present study is also in extension to our program for the synthesis and crystallographic studies of tranexamic acid [25][26]. Topological studies are also one of the area to explain the networks formed by the hydrogen bonds and other intermolecular interactions [27,28].…”

Crystal structure of 4-{[(naphthalen-2-yl)sulfonylamino]methyl}cyclohexanecarboxylic acid

“…Data collection: APEX2 (Bruker, 2007); cell refinement: SAINT (Bruker, 2007); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 for Windows (Farrugia, 2012) and PLATON (Spek, 2009); software used to prepare material for publication: WinGX (Farrugia, 2012) and PLATON. methoxybenzenesulfonamido)methyl)cyclohexane-1-carboxylic acid (Ashfaq et al, 2011b).…”