4-[(3-Phenyl-4,5-dihydroisoxazol-5-yl)methyl]-2H-benzo[b][1,4]thiazin-3(4H)-one

Abstract

In the title compound, C18H16N2O2S, the 5-dihydroisoxazol-5-yl ring and its phenyl substituent are nearly coplanar, with the largest deviation from the mean plane being 0.0184 (16) Å. The thiomorpholin-3-one ring adopts a screw-boat conformation and the attached benzene ring makes a dihedral angle of 42.26 (7)° with the mean plane through the 3-phenyl-4,5-dihydroisoxazol-5-yl ring system. In the crystal, molecules are linked by pairs of C—H...N hydrogen bonds, forming inversion dimers. These dimers are linkedviaC—H...O hydrogen bonds, generating a three-dimensional network.

Crystal structure, Hirshfeld surface analysis and interaction energy and DFT studies of 3-{(2Z)-2-[(2,4-dichlorophenyl)methylidene]-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-4-yl}propanenitrile

“…These molecules exhibit a wide range of biological applications indicating that the 1,4-benzothiazine moiety is a potentially useful template in medicinal chemistry research and has therapeutic applications as anti-inflammatory (Trapani et al, 1985;Gowda et al, 2011), antipyretic (Warren & Knaus, 1987), anti-microbial (Armenise et al, 2012;Rathore & Kumar, 2006;Sabatini et al, 2008), anti-viral (Malagu et al, 1998), anti-cancer (Gupta et al, 1985;Gupta & Gupta, 1991) and anti-oxidant (Zia-ur-Rehman et al, 2009) agents. 1,4-Benzothiazine derivatives have also been reported as precursors for the syntheses of new compounds (Sebbar et al, 2015a;Vidal et al, 2006) possessing anti-diabetic (Tawada et al, 1990) and anti-corrosion activities (Ellouz et al, 2016a,b; ISSN 2056-9890 Sebbar et al, 2016a). They also possess biological properties (Hni et al, 2019a;Saber et al, 2018;Ellouz et al, 2017aEllouz et al, ,b, 2018Sebbar et al, 2017).…”

5,6-Dimethyl-2-[(5-methyl-1,2-oxazol-3-yl)methyl]-1-(prop-2-en-1-yl)-1H-1,3-benzodiazole

“…Isoxazole derivatives with a variety of substituents are known to have various biological activities in both the pharmaceutical and agricultural areas (Lang & Lin, 1984;Boyd, 1991). As a continuation of our previous studies (Sebbar et al, 2015(Sebbar et al, , 2016El Azzaoui et al, 2006), we were interested in the synthesis and the crystal structure of the title compound (Fig. 1).…”

Crystal structure, Hirshfeld surface analysis and interaction energy and DFT studies of (2Z)-4-benzyl-2-(2,4-dichlorobenzylidene)-2H-1,4-benzothiazin-3(4H)-one

“…These molecules exhibit a wide range of biological applications, indicating the fact that the 1,4-benzothiazine moiety is a template potentially useful in medicinal chemistry research and therapeutic applications, such as the anti-inflammatory (Trapani et al, 1985;Gowda et al, 2011), antipyretic (Warren & Knaus, 1987), antimicrobial (Armenise et al, 2012;Rathore & Kumar, 2006), antiviral (Malagu et al, 1998), anticancer (Gupta et al, 1985;Gupta & Gupta, 1991) and anti-oxidant (Zia-ur-Rehman et al, 2009) areas. They have also been reported as precursors for the syntheses of new compounds Vidal et al, 2006) possessing antidiabetic (Tawada et al, 1990) and anticorrosion activities (Ellouz et al, 2016a,b;Sebbar et al, 2016a). They also possess biological properties (Hni et al, 2019a,b;Sebbar et al, 2017;Ellouz et al, 2017aEllouz et al, ,b, 2018.…”