[4+3] Cycloadditions of Enolsilane Derivatives

Dearomative (4 + 3) Cycloaddition Reactions of 3-Alkenylindoles and 3-Alkenylpyrroles to Afford Cyclohepta[b]indoles and Cyclohepta[b]pyrroles

“… 5 Inspired by the fundamental importance of this scaffold, we considered four different routes for its direct construction via dearomatizing (4 + 3) cycloaddition reactions of simple precursors, with each route conferring distinct capabilities for the synthesis of the ambiguines and other natural products ( Figure 2 ). 6 , 7 …”

Construction of Polyfunctionalized 6–5–5 Fused Tricyclic Carbocycles via One-Pot Sequential Semipinacol Rearrangement/Michael Addition/Henry Reaction

“…However, because of their rigidity and steric hindrance, the efficient synthesis of polycarbocyclic molecules still remains a considerable challenge for chemists, although a series of synthetic strategies have emerged. These reported strategies mainly include some complicated organic ring-formation transformations, such as the Diels–Alder reaction, cycloadditions, and polyene cyclization . Tandem reactions, particularly those involving the formation, cleavage, and reorganization of multiple C–C bonds, are generally recognized as one of the most powerful approaches for the construction of complex frameworks.…”