4′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-carboxylic acid: Synthetic approaches, single crystal X-ray structures and antimicrobial activity of intermediates

Synthesis and characterization of new pyrazole–tetrazole derivatives as new vasorelaxant agents

“…N ‐heterocyclic compounds have attracted much interest in several fields and more especially in medicinal chemistry (Brown, 1998). In fact, they have been found to act as potent antimicrobial (Ardeleanu et al, 2018; Dahmani et al, 2021; Harit, Bellaouchi, Mokhtari, et al, 2017), antiviral (Carta et al, 2019), anti‐inflammatory (Kumbar et al, 2018), antitumor (Zhang et al, 2019), and enzyme agents (Kattimani et al, 2020). In this context, several N ‐heterocyclic molecules with well‐defined architectures possessing good biological activities have been investigated in our laboratory, including macrocycles (Harit et al, 2018; Harit, Bellaouchi, Rokni, et al, 2017) and tripods (Harit et al, 2012; Malek et al, 2014).…”

Mesitylene Tribenzoic Acid as a Linker for Novel Zn/Cd Metal-Organic Frameworks

“…In the past few years, our interest in the field has led to several new Metal-Organic Frameworks, as well as a number of organic linkers that can be used in MOF design [24][25][26][27][28][29][30][31][32][33][34][35][36]. With the goal of obtaining novel MOFs with permanent porosity which have the potential to be used for gas storage, in this work we synthesized and characterized three new Metal-Organic Frameworks, obtained using Zn (II) and Cd (II) as metal sources and 2,4,6-tris(4carboxyphenyl)-1,3,5-trimethylbenzene (mesitylene tribenzoic acid-H 3 MTB) an organic linker which to this day, has only seen limited use in MOF design.…”